Skip to main content



Page 5 of 6

  1. Content type: Research

    LINE-1 (L1) is the dominant category of transposable elements in placental mammals. L1 has significantly affected the size and structure of all mammalian genomes and understanding the nature of the interaction...

    Authors: Akash Sookdeo, Crystal M Hepp, Marcella A McClure and Stéphane Boissinot

    Citation: Mobile DNA 2013 4:3

    Published on:

  2. Content type: Research

    A large subfamily of serine recombinases contains long polypeptide segments appended to the C-terminal end of the conserved catalytic domain. Members of this subfamily often function as phage integrases but al...

    Authors: Sridhar Mandali, Gautam Dhar, Nuraly K Avliyakulov, Michael J Haykinson and Reid C Johnson

    Citation: Mobile DNA 2013 4:2

    Published on:

  3. Content type: Software

    High-throughput deep-sequencing technology has generated an unprecedented number of expressed sequence reads that offer the opportunity to get insight into biological systems. Several databases report the sequ...

    Authors: Jeremy Dufourt, Pierre Pouchin, Pierre Peyret, Emilie Brasset and Chantal Vaury

    Citation: Mobile DNA 2013 4:1

    Published on:

  4. Content type: Commentary

    Over the years, a number of reports have revealed that Ty1 integration occurs in a 1-kb window upstream of Pol III-transcribed genes with an approximate 80-bp periodicity between each integration hotspot and t...

    Authors: Antoine Bridier-Nahmias and Pascale Lesage

    Citation: Mobile DNA 2012 3:22

    Published on:

  5. Content type: Research

    Endogenous retroviruses (ERVs) are remnants of exogenous retroviruses that have integrated into the nuclear DNA of a germ-line cell. Here we present the results of a survey into the ERV complement of Crocodylus p...

    Authors: Amanda Yoon-Yee Chong, Sarah Jane Atkinson, Sally Isberg and Jaime Gongora

    Citation: Mobile DNA 2012 3:20

    Published on:

  6. Content type: Meeting Report

    The third international conference on the genomic impact of eukaryotic transposable elements (TEs) was held 24 to 28 February 2012 at the Asilomar Conference Center, Pacific Grove, CA, USA. Sponsored in part b...

    Authors: Irina R Arkhipova, Mark A Batzer, Juergen Brosius, Cédric Feschotte, John V Moran, Jürgen Schmitz and Jerzy Jurka

    Citation: Mobile DNA 2012 3:19

    Published on:

  7. Content type: Software

    Long terminal repeat (LTR) retrotransposons are a class of eukaryotic mobile elements characterized by a distinctive sequence similarity-based structure. Hence they are well suited for computational identifica...

    Authors: Sascha Steinbiss, Sascha Kastens and Stefan Kurtz

    Citation: Mobile DNA 2012 3:18

    Published on:

  8. Content type: Meeting Report

    An international conference on Transposable Elements (TEs) was held 21–24 April 2012 in Saint Malo, France. Organized by the French Transposition Community (GDR Elements Génétiques Mobiles et Génomes, CNRS) an...

    Authors: Abdelkader Ainouche, Mireille Bétermier, Mick Chandler, Richard Cordaux, Gaël Cristofari, Jean-Marc Deragon, Pascale Lesage, Olivier Panaud, Hadi Quesneville, Chantal Vaury, Cristina Vieira and Clémentine Vitte

    Citation: Mobile DNA 2012 3:17

    Published on:

  9. Content type: Research

    Miniature inverted-repeat transposable elements (MITEs) are short, nonautonomous DNA elements flanked by subterminal or terminal inverted repeats (TIRs) with no coding capacity. MITEs were originally recognize...

    Authors: Maríndia Deprá, Adriana Ludwig, Vera LS Valente and Elgion LS Loreto

    Citation: Mobile DNA 2012 3:13

    Published on:

  10. Content type: Research

    Long-terminal repeat (LTR) retrotransposons have complex modes of mobility involving reverse transcription of their RNA genomes in cytoplasmic virus-like particles (VLPs) and integration of the cDNA copies int...

    Authors: Jenni K Risler, Alison E Kenny, Ryan J Palumbo, Eric R Gamache and M Joan Curcio

    Citation: Mobile DNA 2012 3:12

    Published on:

  11. Content type: Short Report

    The vast majority of the 1.1 million Alu elements are retrotranspositionally inactive, where only a few loci referred to as ‘source elements’ can generate new Alu insertions. The first step in identifying the ...

    Authors: Andrew J Oler, Stephen Traina-Dorge, Rebecca S Derbes, Donatella Canella, Brad R Cairns and Astrid M Roy-Engel

    Citation: Mobile DNA 2012 3:11

    Published on:

  12. Content type: Short Report

    Functional regulatory sequences are present in many transposable element (TE) copies, resulting in TEs being frequently exapted by host genes. Today, many examples of TEs impacting host gene expression can be ...

    Authors: Rita Rebollo, Sharareh Farivar and Dixie L Mager

    Citation: Mobile DNA 2012 3:9

    Published on:

  13. Content type: Research

    Sequence analysis of the orangutan genome revealed that recent proliferative activity of Alu elements has been uncharacteristically quiescent in the Pongo (orangutan) lineage, compared with all previously studied...

    Authors: Jerilyn A Walker, Miriam K Konkel, Brygg Ullmer, Christopher P Monceaux, Oliver A Ryder, Robert Hubley, Arian FA Smit and Mark A Batzer

    Citation: Mobile DNA 2012 3:8

    Published on:

  14. Content type: Research

    The H-NS protein is a global regulator of gene expression in bacteria and can also bind transposition complexes (transpososomes). In Tn5 transposition H-NS promotes transpososome assembly in vitro and disruption ...

    Authors: Crystal R Whitfield, Brian H Shilton and David B Haniford

    Citation: Mobile DNA 2012 3:7

    Published on:

  15. Content type: Research

    Tyrosine-based site-specific recombinases (TBSSRs) are DNA breaking-rejoining enzymes. In bacterial genomes, they play a major role in the comings and goings of mobile genetic elements (MGEs), such as temperat...

    Authors: Rob Van Houdt, Raphael Leplae, Gipsi Lima-Mendez, Max Mergeay and Ariane Toussaint

    Citation: Mobile DNA 2012 3:6

    Published on:

  16. Content type: Short Report

    Transposons, segments of DNA that can mobilize to other locations in a genome, are often used for insertion mutagenesis or to generate priming sites for sequencing of large DNA molecules. For both of these use...

    Authors: Brian Green, Christiane Bouchier, Cécile Fairhead, Nancy L Craig and Brendan P Cormack

    Citation: Mobile DNA 2012 3:3

    Published on:

  17. Content type: Research

    Transposable elements (TEs) are major contributors to genome evolution. One factor that influences their evolutionary dynamics is whether their host reproduces through selfing or through outcrossing. According...

    Authors: Nicole de la Chaux, Takashi Tsuchimatsu, Kentaro K Shimizu and Andreas Wagner

    Citation: Mobile DNA 2012 3:2

    Published on:

  18. Content type: Research

    Transposition in IS3, IS30, IS21 and IS256 insertion sequence (IS) families utilizes an unconventional two-step pathway. A figure-of-eight intermediate in Step I, from asymmetric single-strand cleavage and joinin...

    Authors: Leslie A Lewis, Mekbib Astatke, Peter T Umekubo, Shaheen Alvi, Robert Saby, Jehan Afrose, Pedro H Oliveira, Gabriel A Monteiro and Duarte MF Prazeres

    Citation: Mobile DNA 2012 3:1

    Published on:

  19. Content type: Research

    The Sleeping Beauty (SB) transposon system has been used for germline transgenesis of the diploid frog, Xenopus tropicalis. Injecting one-cell embryos with plasmid DNA harboring an SB transposon substrate togethe...

    Authors: Donald A Yergeau, Clair M Kelley, Emin Kuliyev, Haiqing Zhu, Michelle R Johnson Hamlet, Amy K Sater, Dan E Wells and Paul E Mead

    Citation: Mobile DNA 2011 2:15

    Published on:

  20. Content type: Research

    The two-step transposition pathway of insertion sequences of the IS3 family, and several other families, involves first the formation of a branched figure-of-eight (F-8) structure by an asymmetric single strand c...

    Authors: Leslie A Lewis, Mekbib Astatke, Peter T Umekubo, Shaheen Alvi, Robert Saby and Jehan Afrose

    Citation: Mobile DNA 2011 2:14

    Published on:

  21. Content type: Research

    The human genome contains approximately one million Alu elements which comprise more than 10% of human DNA by mass. Alu elements possess direction, and are distributed almost equally in positive and negative stra...

    Authors: George W Cook, Miriam K Konkel, James D Major III, Jerilyn A Walker, Kyudong Han and Mark A Batzer

    Citation: Mobile DNA 2011 2:10

    Published on:

  22. Content type: Research

    Integrons are found in hundreds of environmental bacterial species, but are mainly known as the agents responsible for the capture and spread of antibiotic-resistance determinants between Gram-negative pathoge...

    Authors: Guillaume Cambray, Neus Sanchez-Alberola, Susana Campoy, Émilie Guerin, Sandra Da Re, Bruno González-Zorn, Marie-Cécile Ploy, Jordi Barbé, Didier Mazel and Ivan Erill

    Citation: Mobile DNA 2011 2:6

    Published on:

  23. Content type: Methodology

    The transposon-based gene delivery technique is emerging as a method of choice for gene therapy. The Sleeping Beauty (SB) system has become one of the most favored methods, because of its efficiency and its rando...

    Authors: Orsolya Kolacsek, Virág Krízsik, Anita Schamberger, Zsuzsa Erdei, Ágota Apáti, György Várady, Lajos Mátés, Zsuzsanna Izsvák, Zoltán Ivics, Balázs Sarkadi and Tamás I Orbán

    Citation: Mobile DNA 2011 2:5

    Published on:

    The Erratum to this article has been published in Mobile DNA 2013 4:11

  24. Content type: Research

    The centromeric and pericentromeric regions of plant chromosomes are colonized by Ty3/gypsy retrotransposons, which, on the basis of their reverse transcriptase sequences, form the chromovirus CRM clade. Despi...

    Authors: Pavel Neumann, Alice Navrátilová, Andrea Koblížková, Eduard Kejnovský, Eva Hřibová, Roman Hobza, Alex Widmer, Jaroslav Doležel and Jiří Macas

    Citation: Mobile DNA 2011 2:4

    Published on:

  25. Content type: Research

    Long interspersed elements, type 1(LINE-1, L1) are the most abundant and only active autonomous retrotransposons in the human genome. Native L1 elements are inefficiently expressed because of a transcription e...

    Authors: Wenfeng An, Lixin Dai, Anna Maria Niewiadomska, Alper Yetil, Kathryn A O'Donnell, Jeffrey S Han and Jef D Boeke

    Citation: Mobile DNA 2011 2:2

    Published on:

  26. Content type: Research

    Completed genome projects have revealed an astonishing diversity of transposable genetic elements, implying the existence of novel element families yet to be discovered from diverse life forms. Concurrently, s...

    Authors: Maria I Pajunen, Tiina S Rasila, Lotta J Happonen, Arja Lamberg, Saija Haapa-Paananen, Saija Kiljunen and Harri Savilahti

    Citation: Mobile DNA 2010 1:24

    Published on:

  27. Content type: Research

    Cells adapt to various chronic toxic exposures in a multitude of ways to minimize further damage and maximize their growth potential. Expression of L1 elements in the human genome can be greatly deleterious to...

    Authors: Nicholas A Wallace, Victoria P Belancio, Zach Faber and Prescott Deininger

    Citation: Mobile DNA 2010 1:22

    Published on:

  28. Content type: Meeting Report

    An international conference on mobile DNA was held 24-28 April 2010 in Montreal, Canada. Sponsored by the American Society for Microbiology, the conference's goal was to bring together researchers from around ...

    Authors: George Chaconas, Nancy Craig, M Joan Curcio, Prescott Deininger, Cedric Feschotte, Henry Levin, Phoebe A Rice and Daniel F Voytas

    Citation: Mobile DNA 2010 1:20

    Published on:

  29. Content type: Research

    Retrotransposons are abundant components of plant genomes, and although some plant retrotransposons have been used as insertional mutagens, these mobile genetic elements have not been widely exploited for plan...

    Authors: Yi Hou, Jyothi Rajagopal, Phillip A Irwin and Daniel F Voytas

    Citation: Mobile DNA 2010 1:19

    Published on:

  30. Content type: Research

    Tight regulation of transposition activity is essential to limit damage transposons may cause by generating potentially lethal DNA rearrangements. Assembly of a bona fide protein-DNA complex, the transpososome...

    Authors: Philippe Rousseau, Catherine Tardin, Nathalie Tolou, Laurence Salomé and Mick Chandler

    Citation: Mobile DNA 2010 1:16

    Published on:

Annual Journal Metrics