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Research
The ongoing mobilization of mammalian transposable elements (TEs) contributes to natural genetic variation. To survey the epigenetic control and expression of reporter genes inserted by L1 retrotransposition i...
Mobile DNA 2017 8:8
Published on: 10 May 2017
Research
The presence of transposable elements (TEs) in genomes is known to explain in part the variations of genome sizes among eukaryotes. Even among closely related species, the variation of TE amount may be strikin...
Mobile DNA 2017 8:7
Published on: 27 April 2017
Research
Polymorphic Alu elements account for 17% of structural variants in the human genome. The majority of these belong to the youngest AluY subfamilies, and most structural variant discovery efforts have focused on id...
Mobile DNA 2017 8:6
Published on: 24 April 2017
Software
Population genomic analysis of transposable elements has greatly benefited from recent advances of sequencing technologies. However, the short size of the reads and the propensity of transposable elements to n...
Mobile DNA 2017 8:5
Published on: 8 April 2017
Research
Retrotransposons comprise a ubiquitous and abundant class of eukaryotic transposable elements. All members of this class rely on reverse transcriptase activity to produce a DNA copy of the element from the RNA...
Mobile DNA 2017 8:4
Published on: 14 March 2017
Methodology
High-throughput sequencing (HTS) has revolutionized the way in which epigenetic research is conducted. When coupled with fully-sequenced genomes, millions of small RNA (sRNA) reads are mapped to regions of int...
Mobile DNA 2017 8:3
Published on: 15 February 2017
Research
Transposable elements (TEs) comprise ~10% of the chicken (Gallus gallus) genome. The content of TEs is much lower than that of mammalian genomes, where TEs comprise around half of the genome. Endogenous retroviru...
Mobile DNA 2017 8:2
Published on: 24 January 2017
Research
Mutator-like transposable elements (MULEs) are widespread with members in fungi, plants, and animals. Most of the research on the MULE superfamily has focused on plant MULEs where they...
Mobile DNA 2017 8:1
Published on: 11 January 2017
Research
Helitrons are eukaryotic rolling circle transposable elements that can have a large impact on host genomes due to their copy-number and their ability to capture and copy genes and regulatory elements. They occ...
Mobile DNA 2016 7:27
Published on: 9 December 2016
Meeting report
The third Japanese meeting entitled “Biological Function and Evolution through Interactions between Hosts and Transposable Elements (TEs)” was held on 5–6 September 2016 at National Institute of Genetics (NIG)...
Mobile DNA 2016 7:26
Published on: 7 December 2016
Research
Human endogenous retroviruses (HERVs) constitute 8% of the human genome and contribute substantially to the transcriptome. HERVs have been shown to generate RNAs that modulate host gene expression. However, ex...
Mobile DNA 2016 7:25
Published on: 7 December 2016
Review
Cancer arises from a series of genetic and epigenetic changes, which result in abnormal expression or mutational activation of oncogenes, as well as suppression/inactivation of tumor suppressor genes. Aberrant...
Mobile DNA 2016 7:24
Published on: 1 December 2016
Research
The Long INterspersed Element-1 (L1, LINE-1) is the only autonomous mobile DNA element in humans and has generated as much as half of the genome. Due to increasing clinical interest in the roles of L1 in cance...
Mobile DNA 2016 7:23
Published on: 22 November 2016
Research
LINE-1 (L1) retrotransposons are a notable endogenous source of mutagenesis in mammals. Notably, cancer cells can support unusual L1 retrotransposition and L1-associated sequence rearrangement mechanisms follo...
Mobile DNA 2016 7:21
Published on: 11 November 2016
Research
Gliomas are the most common primary brain tumors in adults. We sought to understand the roles of endogenous transposable elements in these malignancies by identifying evidence of somatic retrotransposition in ...
Mobile DNA 2016 7:22
Published on: 11 November 2016
Research
The National Cancer Institute-60 (NCI-60) cell lines are among the most widely used models of human cancer. They provide a platform to integrate DNA sequence information, epigenetic data, RNA and protein expre...
Mobile DNA 2016 7:20
Published on: 31 October 2016
Meeting report
The third international conference on Transposable Elements (ICTE) was held 16–19 April 2016 in Saint Malo, France. Organized by the French Transposition Community (Research group of the CNRS: “Mobile genetic ...
Mobile DNA 2016 7:19
Published on: 20 October 2016
Short report
Retrotransposed genes are different to other types of genes as they originate from a processed mRNA and are then inserted back into the genome. For a long time, the contribution of this mechanism to the origin...
Mobile DNA 2016 7:18
Published on: 19 October 2016
Research
In gene-dense genomes, mobile elements are confronted with highly selective pressure to amplify without causing excessive damage to the host. The targeting of tRNA genes as potentially safe integration sites h...
Mobile DNA 2016 7:17
Published on: 31 August 2016
Review
Retrotransposons have generated about 40 % of the human genome. This review examines the strategies the cell has evolved to coexist with these genomic “parasites”, focussing on the non-long terminal repeat ret...
Mobile DNA 2016 7:16
Published on: 11 August 2016
Research
Mobile element insertions are a major source of human genomic variation. SVA (SINE-R/VNTR/Alu) is the youngest retrotransposon family in the human genome and a number of diseases are known to be caused by SVA ...
Mobile DNA 2016 7:15
Published on: 30 July 2016
Research
The genomic data available nowadays has enabled the study of repetitive sequences and their relationship to viruses. Among them, long terminal repeat retrotransposons (LTR-RTs) are the largest component of mos...
Mobile DNA 2016 7:14
Published on: 28 July 2016
Obituary
Mobile DNA 2016 7:13
Published on: 26 July 2016
Research
Around 40 million years ago DNA transposons began accumulating in an ancestor of bats in the family Vespertilionidae. Since that time, Class II transposons have been continuously reinvading and accumulating in...
Mobile DNA 2016 7:12
Published on: 22 July 2016
Research
The Pokey family of DNA transposons consists of two putatively autonomous groups, PokeyA and PokeyB, and two groups of Miniature Inverted-repeat Transposable Elements (MITEs), mPok1 and mPok2. This TE family is u...
Mobile DNA 2016 7:11
Published on: 17 June 2016
