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  1. Research

    Detection of the LINE-1 retrotransposon RNA-binding protein ORF1p in different anatomical regions of the human brain

    Recent reports indicate that retrotransposons – a type of mobile DNA – can contribute to neuronal genetic diversity in mammals. Retrotransposons are genetic elements that mobilize via an RNA intermediate by a ...

    Debpali Sur, Raj Kishor Kustwar, Savita Budania, Anita Mahadevan, Dustin C. Hancks, Vijay Yadav, S. K. Shankar and Prabhat K. Mandal

    Mobile DNA 2017 8:17

    Published on: 22 November 2017

  2. Research

    Identification of a novel HERV-K(HML10): comprehensive characterization and comparative analysis in non-human primates provide insights about HML10 proviruses structure and diffusion

    About half of the human genome is constituted of transposable elements, including human endogenous retroviruses (HERV). HERV sequences represent the 8% of our genetic material, deriving from exogenous infectio...

    Nicole Grandi, Marta Cadeddu, Maria Paola Pisano, Francesca Esposito, Jonas Blomberg and Enzo Tramontano

    Mobile DNA 2017 8:15

    Published on: 2 November 2017

  3. Research

    TGTT and AACA: two transcriptionally active LTR retrotransposon subfamilies with a specific LTR structure and horizontal transfer in four Rosaceae species

    Long terminal repeat retrotransposons (LTR-RTs) are major components of plant genomes. Common LTR-RTs contain the palindromic dinucleotide 5′-‘TG’–‘CA’-3′ motif at the ends. Thus, further analyses of non-canon...

    Hao Yin, Xiao Wu, Dongqing Shi, Yangyang Chen, Kaijie Qi, Zhengqiang Ma and Shaoling Zhang

    Mobile DNA 2017 8:14

    Published on: 27 October 2017

  4. Research

    Diversity of P-element piRNA production among M' and Q strains and its association with P-M hybrid dysgenesis in Drosophila melanogaster

    Transposition of P elements in the genome causes P–M hybrid dysgenesis in Drosophila melanogaster. For the P strain, the P–M phenotypes are associated with the ability to express a class of small RNAs, called piw...

    Keiko Tsuji Wakisaka, Kenji Ichiyanagi, Seiko Ohno and Masanobu Itoh

    Mobile DNA 2017 8:13

    Published on: 23 October 2017

  5. Research

    Evolutionary history of the mariner element galluhop in avian genomes

    Transposable elements (TEs) are highly abundant genomic parasites in eukaryote genomes. Although several genomes have been screened for TEs, so far very limited information is available regarding avian TEs and...

    Natasha Avila Bertocchi, Fabiano Pimentel Torres, Analía del Valle Garnero, Ricardo José Gunski and Gabriel Luz Wallau

    Mobile DNA 2017 8:11

    Published on: 14 August 2017

  6. Research

    Discovery of rare, diagnostic AluYb8/9 elements in diverse human populations

    Polymorphic human Alu elements are excellent tools for assessing population structure, and new retrotransposition events can contribute to disease. Next-generation sequencing has greatly increased the potential t...

    Julie Feusier, David J. Witherspoon, W. Scott Watkins, Clément Goubert, Thomas A. Sasani and Lynn B. Jorde

    Mobile DNA 2017 8:9

    Published on: 27 July 2017

  7. Research

    Dynamic silencing of somatic L1 retrotransposon insertions reflects the developmental and cellular contexts of their genomic integration

    The ongoing mobilization of mammalian transposable elements (TEs) contributes to natural genetic variation. To survey the epigenetic control and expression of reporter genes inserted by L1 retrotransposition i...

    Manoj Kannan, Jingfeng Li, Sarah E. Fritz, Kathryn E. Husarek, Jonathan C. Sanford, Teresa L. Sullivan, Pawan Kumar Tiwary, Wenfeng An, Jef D. Boeke and David E. Symer

    Mobile DNA 2017 8:8

    Published on: 10 May 2017

  8. Research

    Convergence of retrotransposons in oomycetes and plants

    Retrotransposons comprise a ubiquitous and abundant class of eukaryotic transposable elements. All members of this class rely on reverse transcriptase activity to produce a DNA copy of the element from the RNA...

    Kirill Ustyantsev, Alexandr Blinov and Georgy Smyshlyaev

    Mobile DNA 2017 8:4

    Published on: 14 March 2017

  9. Research

    Non-canonical Helitrons in Fusarium oxysporum

    Helitrons are eukaryotic rolling circle transposable elements that can have a large impact on host genomes due to their copy-number and their ability to capture and copy genes and regulatory elements. They occ...

    Biju Vadakkemukadiyil Chellapan, Peter van Dam, Martijn Rep, Ben J. C. Cornelissen and Like Fokkens

    Mobile DNA 2016 7:27

    Published on: 9 December 2016

  10. Research

    The intron-enriched HERV-K(HML-10) family suppresses apoptosis, an indicator of malignant transformation

    Human endogenous retroviruses (HERVs) constitute 8% of the human genome and contribute substantially to the transcriptome. HERVs have been shown to generate RNAs that modulate host gene expression. However, ex...

    Felix Broecker, Roger Horton, Jochen Heinrich, Alexandra Franz, Michal-Ruth Schweiger, Hans Lehrach and Karin Moelling

    Mobile DNA 2016 7:25

    Published on: 7 December 2016

  11. Review

    Endogenous retroviral promoter exaptation in human cancer

    Cancer arises from a series of genetic and epigenetic changes, which result in abnormal expression or mutational activation of oncogenes, as well as suppression/inactivation of tumor suppressor genes. Aberrant...

    Artem Babaian and Dixie L. Mager

    Mobile DNA 2016 7:24

    Published on: 1 December 2016

  12. Research

    Somatic retrotransposition is infrequent in glioblastomas

    Gliomas are the most common primary brain tumors in adults. We sought to understand the roles of endogenous transposable elements in these malignancies by identifying evidence of somatic retrotransposition in ...

    Pragathi Achanta, Jared P. Steranka, Zuojian Tang, Nemanja Rodić, Reema Sharma, Wan Rou Yang, Sisi Ma, Mark Grivainis, Cheng Ran Lisa Huang, Anna M. Schneider, Gary L. Gallia, Gregory J. Riggins, Alfredo Quinones-Hinojosa, David Fenyö, Jef D. Boeke and Kathleen H. Burns

    Mobile DNA 2016 7:22

    Published on: 11 November 2016

  13. Research

    Evidence for L1-associated DNA rearrangements and negligible L1 retrotransposition in glioblastoma multiforme

    LINE-1 (L1) retrotransposons are a notable endogenous source of mutagenesis in mammals. Notably, cancer cells can support unusual L1 retrotransposition and L1-associated sequence rearrangement mechanisms follo...

    Patricia E. Carreira, Adam D. Ewing, Guibo Li, Stephanie N. Schauer, Kyle R. Upton, Allister C. Fagg, Santiago Morell, Michaela Kindlova, Patricia Gerdes, Sandra R. Richardson, Bo Li, Daniel J. Gerhardt, Jun Wang, Paul M. Brennan and Geoffrey J. Faulkner

    Mobile DNA 2016 7:21

    Published on: 11 November 2016

  14. Research

    A map of mobile DNA insertions in the NCI-60 human cancer cell panel

    The National Cancer Institute-60 (NCI-60) cell lines are among the most widely used models of human cancer. They provide a platform to integrate DNA sequence information, epigenetic data, RNA and protein expre...

    John G. Zampella, Nemanja Rodić, Wan Rou Yang, Cheng Ran Lisa Huang, Jane Welch, Veena P. Gnanakkan, Toby C. Cornish, Jef D. Boeke and Kathleen H. Burns

    Mobile DNA 2016 7:20

    Published on: 31 October 2016

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