Mobile DNA

Comparative analysis on the expression of L1 loci using various RNA-Seq preparations

The role of DNA methylation in aging has been widely studied. However, epigenetic mutations, here defined as aberrant methylation levels compared to the distribution in a population, are less understood. For this Methodology, our authors developed whole-cell, cytoplasmic and nuclear RNA-Seq datasets from 22Rv1 prostate cancer cells to test the influence of different preparations on the quality and effort needed to measure L1 expression.

The Editors of Mobile DNA and Retrovirology extend an invitation to submit original research articles related to endogenous retroviruses to their new collection: Endogenous Retroviruses in Evolution and Disease.

Open for submissions: May 24, 2019

Submit an article to Mobile DNA for the series.

The Editors-in-Chief of Mobile DNA welcome authors to send any pre-submission inquiries they might have to the Editorial Email address, which can be found here by clicking on "Contact Us" (upper left side of page). We ask that you please include “Pre-submission inquiry” in the subject line of your email and that you include the title and abstract of your proposed submission within the message. Our Editors will do their best to respond to you in a timely manner.

Highlights from recent literature on mobile elements, selected by the Editors-in-Chief.

Pan-cancer analysis of whole genomes identifies driver rearrangements promoted by LINE-1 retrotransposition [Nat Genet. 2020] PubMed

LUMI-PCR: an Illumina platform ligation-mediated PCR protocol for integration site cloning, provides molecular quantitation of integration sites [Mob DNA 2020] PubMed

BRCA1 and S phase DNA repair pathways restrict LINE-1 retrotransposition in human cells [Nat Struct Mol Biol 2020] PubMed

Cell fitness screens reveal a conflict between LINE-1 retrotransposition and DNA replication [Nat Struct Mol Biol 2020] PubMed

Transposon Insertion Mutagenesis in Mice for Modeling Human Cancers: Critical Insights Gained and New Opportunities [Int J Mol Sci 2020] PubMed

View all editors' picks

Irina Arkhipova, Marine Biological Laboratory at Woods Hole
Cédric Feschotte, Cornell University
Haig Kazazian, Johns Hopkins University
Henry Levin, NIH

In 2019, we welcomed our new Associate Editors: 
Orsolya Barabas, European Molecular Biology Laboratory (EMBL), Germany
Gael Cristofari, Institut National de la Santé et de la Recherche Médicale, France 
Adam Ewing, Mater Research Institute-University of Queensland, Australia
Clément Gilbert, CNRS, Université Paris Saclay, France 
Molly G Hammell, Cold Spring Harbor Laboratory, USA
Damon R Lisch, Purdue University, USA
Joe Peters, Cornell University, USA
Phoebe Rice, The University of Chicago, USA

Updated monthly, check out the newest published research on transposable elements in the TE Digest on Alexander Suh of Uppsala University's Genomicrocosm page here. 

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4th International Congress on Transposable Elements - April 25-28, 2020 - Saint Malo, France