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  1. Transposable elements (TE) are commonly regarded as “junk DNA” with no apparent regulatory roles in the human genome. However, a growing body of evidence demonstrates that some TEs exhibit regulatory activitie...

    Authors: Jiayue-Clara Jiang and Kyle R. Upton

    Citation: Mobile DNA 2019 10:16

    Content type: Research

    Published on:

  2. Transposable element (TE) insertions are responsible for a significant fraction of spontaneous germ line mutations reported in inbred mouse strains. This major contribution of TEs to the mutational landscape i...

    Authors: Liane Gagnier, Victoria P. Belancio and Dixie L. Mager

    Citation: Mobile DNA 2019 10:15

    Content type: Review

    Published on:

  4. We have recently described a peculiar feature of the promoters in two Drosophila Tc1-like elements, Bari1 and Bari3. The AT-richness and the presence of weak core-promoter motifs make these promoters, that we hav...

    Authors: Antonio Palazzo, Patrizio Lorusso, Csaba Miskey, Oliver Walisko, Andrea Gerbino, Carlo Marya Thomas Marobbio, Zoltán Ivics and René Massimiliano Marsano

    Citation: Mobile DNA 2019 10:13

    Content type: Research

    Published on:

  7. Transposable elements (TEs) are not randomly distributed in the genome. A genome-wide analysis of the D. melanogaster genome found that differences in TE density across 50 kb genomic regions was due both to trans...

    Authors: Miriam Merenciano, Camillo Iacometti and Josefa González

    Citation: Mobile DNA 2019 10:10

    Content type: Short report

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  8. Human stem cells harbor significant potential for basic and clinical translational research as well as regenerative medicine. Currently ~ 3000 adult and ~ 30 pluripotent stem cell-based, interventional clinica...

    Authors: Gerald G. Schumann, Nina V. Fuchs, Pablo Tristán-Ramos, Attila Sebe, Zoltán Ivics and Sara R. Heras

    Citation: Mobile DNA 2019 10:9

    Content type: Review

    Published on:

  9. Transposable elements make up a significant portion of the human genome. Accurately locating these mobile DNAs is vital to understand their role as a source of structural variation and somatic mutation. To thi...

    Authors: Jared P. Steranka, Zuojian Tang, Mark Grivainis, Cheng Ran Lisa Huang, Lindsay M. Payer, Fernanda O. R. Rego, Thiago Luiz Araujo Miller, Pedro A. F. Galante, Sitharam Ramaswami, Adriana Heguy, David Fenyö, Jef D. Boeke and Kathleen H. Burns

    Citation: Mobile DNA 2019 10:8

    Content type: Methodology

    Published on:

  10. Pseudomonas syringae is a γ-proteobacterium causing economically relevant diseases in practically all cultivated plants. Most isolates of this pathogen contain native plasmids collectively carrying many pathogeni...

    Authors: Leire Bardaji, Maite Añorga, Myriam Echeverría, Cayo Ramos and Jesús Murillo

    Citation: Mobile DNA 2019 10:7

    Content type: Research

    Published on:

  11. Thanks to their ability to move around and replicate within genomes, transposable elements (TEs) are perhaps the most important contributors to genome plasticity and evolution. Their detection and annotation a...

    Authors: Joëlle Amselem, Guillaume Cornut, Nathalie Choisne, Michael Alaux, Françoise Alfama-Depauw, Véronique Jamilloux, Florian Maumus, Thomas Letellier, Isabelle Luyten, Cyril Pommier, Anne-Françoise Adam-Blondon and Hadi Quesneville

    Citation: Mobile DNA 2019 10:6

    Content type: Software

    Published on:

  13. The transfer of genetic material from non-parent organisms is called horizontal gene transfer (HGT). One of the most conclusive cases of HGT in metazoans was previously described for the cellulose synthase gen...

    Authors: Maria A. Daugavet, Sergey Shabelnikov, Alexander Shumeev, Tatiana Shaposhnikova, Leonid S. Adonin and Olga Podgornaya

    Citation: Mobile DNA 2019 10:4

    Content type: Research

    Published on:

  14. Repetitive sequences, including transposable elements (TEs) and satellite DNAs, occupy a considerable portion of plant genomes. Analysis of the repeat fraction benefits the understanding of genome structure an...

    Authors: Shu-Fen Li, Yu-Jiao Guo, Jia-Rong Li, Dong-Xu Zhang, Bing-Xiao Wang, Ning Li, Chuan-Liang Deng and Wu-Jun Gao

    Citation: Mobile DNA 2019 10:3

    Content type: Research

    Published on:

  15. The original article [1] contained an error whereby author Dong Yin’s name was mistakenly inverted. This error has now been corrected.

    Authors: Kaishun Hu, Yu Li, Wenjing Wu, Hengxing Chen, Zhen Chen, Yin Zhang, Yabin Guo and Dong Yin

    Citation: Mobile DNA 2019 10:2

    Content type: Correction

    Published on:

    The original article was published in Mobile DNA 2018 9:33

  16. Plant LTR-retrotransposons are classified into two superfamilies, Ty1/copia and Ty3/gypsy. They are further divided into an enormous number of families which are, due to the high diversity of their nucleotide ...

    Authors: Pavel Neumann, Petr Novák, Nina Hoštáková and Jiří Macas

    Citation: Mobile DNA 2019 10:1

    Content type: Research

    Published on:

  17. The evolution and spread of antibiotic resistance is often mediated by mobile genetic elements. Integrative and conjugative elements (ICEs) are the most abundant conjugative elements among prokaryotes. However...

    Authors: João Botelho, Adam P. Roberts, Ricardo León-Sampedro, Filipa Grosso and Luísa Peixe

    Citation: Mobile DNA 2018 9:37

    Content type: Research

    Published on:

  19. Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease involving loss of motor neurons and having no known cure and uncertain etiology. Several studies have drawn connections between altered ...

    Authors: Gavin C. Pereira, Laura Sanchez, Paul M. Schaughency, Alejandro Rubio-Roldán, Jungbin A. Choi, Evarist Planet, Ranjan Batra, Priscilla Turelli, Didier Trono, Lyle W. Ostrow, John Ravits, Haig H. Kazazian, Sarah J. Wheelan, Sara R. Heras, Jens Mayer, Jose Luis García-Pérez…

    Citation: Mobile DNA 2018 9:35

    Content type: Research

    Published on:

  21. Similar to retro−/lenti- virus system, DNA transposons are useful tools for stable expression of exogenous genes in mammalian cells. Sleeping Beauty (SB) transposon has adopted for integrating genes into host ...

    Authors: Kaishun Hu, Yu Li, Wenjing Wu, Hengxing Chen, Zhen Chen, Yin Zhang, Yabin Guo and Dong Yin

    Citation: Mobile DNA 2018 9:33

    Content type: Research

    Published on:

    The Correction to this article has been published in Mobile DNA 2019 10:2

  22. Although repeat sequences constitute about 37% of carnivore genomes, the characteristics and distribution of repeat sequences among carnivore genomes have not been fully investigated. Based on the updated Repb...

    Authors: Changjun Peng, Lili Niu, Jiabo Deng, Jianqiu Yu, Xueyan Zhang, Chuang Zhou, Jinchuan Xing and Jing Li

    Citation: Mobile DNA 2018 9:32

    Content type: Research

    Published on:

  23. There is increasing evidence that the transpositional activity of retroelements (REs) is not limited to germ line cells, but often occurs in tumor and normal somatic cells. Somatic transpositions were found in...

    Authors: Alexander Y. Komkov, Anastasia A. Minervina, Gaiaz A. Nugmanov, Mariia V. Saliutina, Konstantin V. Khodosevich, Yuri B. Lebedev and Ilgar Z. Mamedov

    Citation: Mobile DNA 2018 9:31

    Content type: Methodology

    Published on:

  26. Transposable elements are biologically important components of eukaryote genomes. In particular, non-LTR retrotransposons (N-LTRrs) played a key role in shaping the human genome throughout evolution. In this s...

    Authors: Etienne Guichard, Valentina Peona, Guidantonio Malagoli Tagliazucchi, Lucia Abitante, Evelyn Jagoda, Margherita Musella, Marco Ricci, Alejandro Rubio-Roldán, Stefania Sarno, Donata Luiselli, Davide Pettener, Cristian Taccioli, Luca Pagani, Jose Luis Garcia-Perez and Alessio Boattini

    Citation: Mobile DNA 2018 9:28

    Content type: Research

    Published on:

  28. The antisense insertion of a canine short interspersed element (SINEC_Cf) in the pigmentation gene PMEL (or SILV) causes a coat pattern phenotype in dogs termed merle. Merle is a semi-dominant trait characterized...

    Authors: Sarah C. Murphy, Jacquelyn M. Evans, Kate L. Tsai and Leigh Anne Clark

    Citation: Mobile DNA 2018 9:26

    Content type: Research

    Published on:

  29. The field of small RNA is one of the most investigated research areas since they were shown to regulate transposable elements and gene expression and play essential roles in fundamental biological processes. S...

    Authors: Romain Pogorelcnik, Chantal Vaury, Pierre Pouchin, Silke Jensen and Emilie Brasset

    Citation: Mobile DNA 2018 9:25

    Content type: Software

    Published on:

  30. Homing endonuclease genes (HEGs) are widely distributed genetic elements in the mitochondrial genomes of a diversity of eukaryotes. Due to their ability to self-propagate within and between genomes, these elem...

    Authors: Zhun Yan, Zhimin Li, Li Yan, Yongting Yu, Yi Cheng, Jia Chen, Yunyun Liu, Chunsheng Gao, Liangbin Zeng, Xiangping Sun, Litao Guo and Jianping Xu

    Citation: Mobile DNA 2018 9:24

    Content type: Research

    Published on:

  31. The majority of Eukaryotic genomes are composed of a small portion of stable (non-mobile) genes and a large fraction of parasitic mobile elements such as transposable elements and endogenous viruses: the Mobil...

    Authors: Alexandre Freitas da Silva, Filipe Zimmer Dezordi, Elgion Lucio Silva Loreto and Gabriel Luz Wallau

    Citation: Mobile DNA 2018 9:23

    Content type: Research

    Published on:

  32. Retrotransposons are transposable elements (TEs) capable of “jumping” in germ, embryonic and tumor cells and, as is now clearly established, in the neuronal lineage. Mosaic TE insertions form part of a broader...

    Authors: Geoffrey J. Faulkner and Victor Billon

    Citation: Mobile DNA 2018 9:22

    Content type: Review

    Published on:

  33. The Mobile Genetic Elements and Genome Plasticity conference was hosted by Keystone Symposia in Santa Fe, NM USA, February 11–15, 2018. The organizers were Marlene Belfort, Evan Eichler, Henry Levin and Lynne ...

    Authors: John M. Abrams, Irina R. Arkhipova, Marlene Belfort, Jef D. Boeke, M. Joan Curcio, Geoffrey J. Faulkner, John L. Goodier, Ruth Lehmann and Henry L. Levin

    Citation: Mobile DNA 2018 9:21

    Content type: Meeting report

    Published on:

  35. Transposable elements (TEs) are common and often present with high copy numbers in cellular genomes. Unlike in cellular organisms, TEs were previously thought to be either rare or absent in viruses. Almost all...

    Authors: Hua-Hao Zhang, Qiu-Zhong Zhou, Ping-Lan Wang, Xiao-Min Xiong, Andrea Luchetti, Didier Raoult, Anthony Levasseur, Sebastien Santini, Chantal Abergel, Matthieu Legendre, Jean-Michel Drezen, Catherine Béliveau, Michel Cusson, Shen-Hua Jiang, Hai-Ou Bao, Cheng Sun…

    Citation: Mobile DNA 2018 9:19

    Content type: Research

    Published on:

  39. In the course of analyzing whole-genome data, it is common practice to mask or filter out repetitive regions of a genome, such as transposable elements and endogenous retroviruses, in order to focus only on ge...

    Authors: R. Keith Slotkin

    Citation: Mobile DNA 2018 9:15

    Content type: Commentary

    Published on:

  41. Since the completion of the human genome project, the diversity of genome sequencing data produced for non-human primates has increased exponentially. Papio baboons are well-established biological models for stud...

    Authors: Vallmer E. Jordan, Jerilyn A. Walker, Thomas O. Beckstrom, Cody J. Steely, Cullen L. McDaniel, Corey P. St. Romain, Kim C. Worley, Jane Phillips-Conroy, Clifford J. Jolly, Jeffrey Rogers, Miriam K. Konkel and Mark A. Batzer

    Citation: Mobile DNA 2018 9:13

    Content type: Research

    Published on:

  42. LINE-1 (L1) is the dominant autonomously replicating non-LTR retrotransposon in mammals. Although our knowledge of L1 evolution across the tree of life has considerably improved in recent years, what we know o...

    Authors: Akash Sookdeo, Crystal M. Hepp and Stéphane Boissinot

    Citation: Mobile DNA 2018 9:12

    Content type: Research

    Published on:

  43. The restriction factor SAMHD1 regulates intracellular nucleotide level by degrading dNTPs and blocks the replication of retroviruses and DNA viruses in non-cycling cells, like macrophages or dendritic cells. I...

    Authors: Alexandra Herrmann, Sabine Wittmann, Dominique Thomas, Caitlin N. Shepard, Baek Kim, Nerea Ferreirós and Thomas Gramberg

    Citation: Mobile DNA 2018 9:11

    Content type: Research

    Published on:

    The Correction to this article has been published in Mobile DNA 2018 9:16

  44. Alu elements are primate-specific retroposons that mobilize using the enzymatic machinery of L1 s. The recently completed baboon genome project found that the mobilization rate of Alu elements is higher than in t...

    Authors: Cody J. Steely, Jasmine N. Baker, Jerilyn A. Walker, Charles D. Loupe III and Mark A. Batzer

    Citation: Mobile DNA 2018 9:10

    Content type: Research

    Published on:

  45. The evolution of Alu elements has been ongoing in primate lineages and Alu insertion polymorphisms are widely used in phylogenetic and population genetics studies. Alu subfamilies in the squirrel monkey (Saimiri)...

    Authors: Jasmine N. Baker, Jerilyn A. Walker, Michael W. Denham, Charles D. Loupe III and Mark A. Batzer

    Citation: Mobile DNA 2018 9:9

    Content type: Research

    Published on:

  47. P-element transposition in the genome causes P-M hybrid dysgenesis in Drosophila melanogaster. Maternally deposited piRNAs suppress P-element transposition in the progeny, linking them to P-M phenotypes; however,...

    Authors: Keiko Tsuji Wakisaka, Kenji Ichiyanagi, Seiko Ohno and Masanobu Itoh

    Citation: Mobile DNA 2018 9:7

    Content type: Research

    Published on:

  49. The genome of the gastric pathogen Helicobacter pylori is characterised by considerable variation of both gene sequence and content, much of which is contained within three large genomic islands comprising the ca...

    Authors: Robin M. Delahay, Nicola J. Croxall and Amberley D. Stephens

    Citation: Mobile DNA 2018 9:5

    Content type: Research

    Published on:

  50. Inteins are mobile, self-splicing sequences that interrupt proteins and occur across all three domains of life. Scrutiny of the intein landscape in prokaryotes led to the hypothesis that some inteins are funct...

    Authors: Cathleen M. Green, Olga Novikova and Marlene Belfort

    Citation: Mobile DNA 2018 9:4

    Content type: Research

    Published on:

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ISSN: 1759-8753