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  1. Content type: Research

    R2 elements are a clade of early branching Long Interspersed Elements (LINEs). LINEs are retrotransposable elements whose replication can have profound effects on the genomes in which they reside. No crystal o...

    Authors: M. Murshida Mahbub, Saiful M. Chowdhury and Shawn M. Christensen

    Citation: Mobile DNA 2017 8:16

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  2. Content type: Research

    About half of the human genome is constituted of transposable elements, including human endogenous retroviruses (HERV). HERV sequences represent the 8% of our genetic material, deriving from exogenous infectio...

    Authors: Nicole Grandi, Marta Cadeddu, Maria Paola Pisano, Francesca Esposito, Jonas Blomberg and Enzo Tramontano

    Citation: Mobile DNA 2017 8:15

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  3. Content type: Research

    Long terminal repeat retrotransposons (LTR-RTs) are major components of plant genomes. Common LTR-RTs contain the palindromic dinucleotide 5′-‘TG’–‘CA’-3′ motif at the ends. Thus, further analyses of non-canon...

    Authors: Hao Yin, Xiao Wu, Dongqing Shi, Yangyang Chen, Kaijie Qi, Zhengqiang Ma and Shaoling Zhang

    Citation: Mobile DNA 2017 8:14

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  4. Content type: Research

    Transposition of P elements in the genome causes P–M hybrid dysgenesis in Drosophila melanogaster. For the P strain, the P–M phenotypes are associated with the ability to express a class of small RNAs, called piw...

    Authors: Keiko Tsuji Wakisaka, Kenji Ichiyanagi, Seiko Ohno and Masanobu Itoh

    Citation: Mobile DNA 2017 8:13

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  5. Content type: Research

    Transposable elements (TEs) are highly abundant genomic parasites in eukaryote genomes. Although several genomes have been screened for TEs, so far very limited information is available regarding avian TEs and...

    Authors: Natasha Avila Bertocchi, Fabiano Pimentel Torres, Analía del Valle Garnero, Ricardo José Gunski and Gabriel Luz Wallau

    Citation: Mobile DNA 2017 8:11

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  6. Content type: Research

    Polymorphic human Alu elements are excellent tools for assessing population structure, and new retrotransposition events can contribute to disease. Next-generation sequencing has greatly increased the potential t...

    Authors: Julie Feusier, David J. Witherspoon, W. Scott Watkins, Clément Goubert, Thomas A. Sasani and Lynn B. Jorde

    Citation: Mobile DNA 2017 8:9

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  7. Content type: Research

    The ongoing mobilization of mammalian transposable elements (TEs) contributes to natural genetic variation. To survey the epigenetic control and expression of reporter genes inserted by L1 retrotransposition i...

    Authors: Manoj Kannan, Jingfeng Li, Sarah E. Fritz, Kathryn E. Husarek, Jonathan C. Sanford, Teresa L. Sullivan, Pawan Kumar Tiwary, Wenfeng An, Jef D. Boeke and David E. Symer

    Citation: Mobile DNA 2017 8:8

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  8. Content type: Research

    Retrotransposons comprise a ubiquitous and abundant class of eukaryotic transposable elements. All members of this class rely on reverse transcriptase activity to produce a DNA copy of the element from the RNA...

    Authors: Kirill Ustyantsev, Alexandr Blinov and Georgy Smyshlyaev

    Citation: Mobile DNA 2017 8:4

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  9. Content type: Research

    Transposable elements (TEs) comprise ~10% of the chicken (Gallus gallus) genome. The content of TEs is much lower than that of mammalian genomes, where TEs comprise around half of the genome. Endogenous retroviru...

    Authors: Jinmin Lee, Seyoung Mun, Dong Hee Kim, Chun-Sung Cho, Dong-Yep Oh and Kyudong Han

    Citation: Mobile DNA 2017 8:2

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  10. Content type: Research

    Helitrons are eukaryotic rolling circle transposable elements that can have a large impact on host genomes due to their copy-number and their ability to capture and copy genes and regulatory elements. They occ...

    Authors: Biju Vadakkemukadiyil Chellapan, Peter van Dam, Martijn Rep, Ben J. C. Cornelissen and Like Fokkens

    Citation: Mobile DNA 2016 7:27

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  11. Content type: Research

    Human endogenous retroviruses (HERVs) constitute 8% of the human genome and contribute substantially to the transcriptome. HERVs have been shown to generate RNAs that modulate host gene expression. However, ex...

    Authors: Felix Broecker, Roger Horton, Jochen Heinrich, Alexandra Franz, Michal-Ruth Schweiger, Hans Lehrach and Karin Moelling

    Citation: Mobile DNA 2016 7:25

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  12. Content type: Review

    Cancer arises from a series of genetic and epigenetic changes, which result in abnormal expression or mutational activation of oncogenes, as well as suppression/inactivation of tumor suppressor genes. Aberrant...

    Authors: Artem Babaian and Dixie L. Mager

    Citation: Mobile DNA 2016 7:24

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  13. Content type: Research

    Gliomas are the most common primary brain tumors in adults. We sought to understand the roles of endogenous transposable elements in these malignancies by identifying evidence of somatic retrotransposition in ...

    Authors: Pragathi Achanta, Jared P. Steranka, Zuojian Tang, Nemanja Rodić, Reema Sharma, Wan Rou Yang, Sisi Ma, Mark Grivainis, Cheng Ran Lisa Huang, Anna M. Schneider, Gary L. Gallia, Gregory J. Riggins, Alfredo Quinones-Hinojosa, David Fenyö, Jef D. Boeke and Kathleen H. Burns

    Citation: Mobile DNA 2016 7:22

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  14. Content type: Research

    LINE-1 (L1) retrotransposons are a notable endogenous source of mutagenesis in mammals. Notably, cancer cells can support unusual L1 retrotransposition and L1-associated sequence rearrangement mechanisms follo...

    Authors: Patricia E. Carreira, Adam D. Ewing, Guibo Li, Stephanie N. Schauer, Kyle R. Upton, Allister C. Fagg, Santiago Morell, Michaela Kindlova, Patricia Gerdes, Sandra R. Richardson, Bo Li, Daniel J. Gerhardt, Jun Wang, Paul M. Brennan and Geoffrey J. Faulkner

    Citation: Mobile DNA 2016 7:21

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  15. Content type: Research

    The National Cancer Institute-60 (NCI-60) cell lines are among the most widely used models of human cancer. They provide a platform to integrate DNA sequence information, epigenetic data, RNA and protein expre...

    Authors: John G. Zampella, Nemanja Rodić, Wan Rou Yang, Cheng Ran Lisa Huang, Jane Welch, Veena P. Gnanakkan, Toby C. Cornish, Jef D. Boeke and Kathleen H. Burns

    Citation: Mobile DNA 2016 7:20

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  16. Content type: Meeting report

    The third international conference on Transposable Elements (ICTE) was held 16–19 April 2016 in Saint Malo, France. Organized by the French Transposition Community (Research group of the CNRS: “Mobile genetic ...

    Authors: Pascale Lesage, Mireille Bétermier, Antoine Bridier-Nahmias, Michael Chandler, Séverine Chambeyron, Gael Cristofari, Nicolas Gilbert, Hadi Quesneville, Chantal Vaury and Jean-Nicolas Volff

    Citation: Mobile DNA 2016 7:19

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  17. Content type: Short report

    Retrotransposed genes are different to other types of genes as they originate from a processed mRNA and are then inserted back into the genome. For a long time, the contribution of this mechanism to the origin...

    Authors: Pengjun Xu, Roberto Feuda, Bin Lu, Haijun Xiao, Robert I. Graham and Kongming Wu

    Citation: Mobile DNA 2016 7:18

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  18. Content type: Review

    Retrotransposons have generated about 40 % of the human genome. This review examines the strategies the cell has evolved to coexist with these genomic “parasites”, focussing on the non-long terminal repeat ret...

    Authors: John L. Goodier

    Citation: Mobile DNA 2016 7:16

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  19. Content type: Research

    The genomic data available nowadays has enabled the study of repetitive sequences and their relationship to viruses. Among them, long terminal repeat retrotransposons (LTR-RTs) are the largest component of mos...

    Authors: Edgar Andres Ochoa Cruz, Guilherme Marcello Queiroga Cruz, Andréia Prata Vieira and Marie-Anne Van Sluys

    Citation: Mobile DNA 2016 7:14

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  20. Content type: Research

    Retrotransposons are mobile elements that have a high impact on shaping the mammalian genomes. Since the availability of whole genomes, genomic analyses have provided novel insights into retrotransposon biolog...

    Authors: Georgios Markopoulos, Dimitrios Noutsopoulos, Stefania Mantziou, Demetrios Gerogiannis, Soteroula Thrasyvoulou, Georgios Vartholomatos, Evangelos Kolettas and Theodore Tzavaras

    Citation: Mobile DNA 2016 7:10

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  21. Content type: Review

    Over evolutionary time, the dynamic nature of a genome is driven, in part, by the activity of transposable elements (TE) such as retrotransposons. On a shorter time scale it has been established that new TE in...

    Authors: Dustin C. Hancks and Haig H. Kazazian Jr.

    Citation: Mobile DNA 2016 7:9

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  22. Content type: Research

    Approximately 17 % of the human genome is comprised of the Long INterspersed Element-1 (LINE-1 or L1) retrotransposon, the only currently active autonomous family of retroelements. Though L1 elements have helped ...

    Authors: Kristine J. Kines, Mark Sokolowski, Dawn L. deHaro, Claiborne M. Christian, Melody Baddoo, Madison E. Smither and Victoria P. Belancio

    Citation: Mobile DNA 2016 7:8

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  23. Content type: Research

    The revolutionary concept of “jumping genes” was conceived by McClintock in the late 1940s while studying the Activator/Dissociation (Ac/Ds) system in maize. Transposable elements (TEs) represent the most abundan...

    Authors: Jun Ni, Kirk J. Wangensteen, David Nelsen, Darius Balciunas, Kimberly J. Skuster, Mark D. Urban and Stephen C. Ekker

    Citation: Mobile DNA 2016 7:6

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  24. Content type: Software

    A critical topic of insertional mutagenesis experiments performed on model organisms is mapping the hits of artificial transposons (ATs) at nucleotide level accuracy. Mapping errors may occur when sequencing a...

    Authors: Alexandru Al. Ecovoiu, Iulian Constantin Ghionoiu, Andrei Mihai Ciuca and Attila Cristian Ratiu

    Citation: Mobile DNA 2016 7:3

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  25. Content type: Research

    Long terminal repeat (LTR)-retrotransposons constitute 42.4 % of the genome of the ‘Suli’ pear (Pyrus pyrifolia white pear group), implying that retrotransposons have played important roles in Pyrus evolution. Th...

    Authors: Shuang Jiang, Danying Cai, Yongwang Sun and Yuanwen Teng

    Citation: Mobile DNA 2016 7:1

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  26. Content type: Research

    A large number of Saccharomyces cerevisiae cellular factors modulate the movement of the retrovirus-like transposon Ty1. Surprisingly, a significant number of chromosomal genes required for Ty1 transposition enco...

    Authors: Susmitha Suresh, Hyo Won Ahn, Kartikeya Joshi, Arun Dakshinamurthy, Arun Kannanganat, David J. Garfinkel and Philip J. Farabaugh

    Citation: Mobile DNA 2015 6:22

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    The Erratum to this article has been published in Mobile DNA 2016 7:5

  27. Content type: Research

    The human genome contains several active families of transposable elements (TE): Alu, L1 and SVA. Germline transposition of these elements can lead to polymorphic TE (polyTE) loci that differ between individua...

    Authors: Lavanya Rishishwar, Carlos E. Tellez Villa and I. King Jordan

    Citation: Mobile DNA 2015 6:21

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  28. Content type: Meeting Report

    The First International Scientific Conference on Human Endogenous Retroviruses (HERVs) and Disease, Lyon-France, May 26-27th 2015, brought together scientific and medical specialists from around the world investi...

    Authors: Avindra Nath, Patrick Küry, Guilherme Sciascia do Olival, Antonina Dolei, Håkan Karlsson, Laurent Groc, Marion Schneider, John Kriesel, Jean-Louis Touraine, François Mallet, Patrice N. Marche, Frederick Arnaud, Cédric Feschotte and Hervé Perron

    Citation: Mobile DNA 2015 6:20

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  29. Content type: Research

    Transposable elements (TEs) are common constituents of centromeres. However, it is not known what causes this relationship. Schizosaccharomyces japonicus contains 10 families of Long Terminal Repeat (LTR)-retrotr...

    Authors: Yabin Guo, Parmit Kumar Singh and Henry L. Levin

    Citation: Mobile DNA 2015 6:19

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  30. Content type: Research

    Repetitive regions of DNA and transposable elements have been found to constitute large percentages of eukaryotic and prokaryotic genomes. Such elements are known to be involved in transcriptional regulation, ...

    Authors: Brian A. Klein, Tsute Chen, Jodie C. Scott, Andrea L. Koenigsberg, Margaret J. Duncan and Linden T. Hu

    Citation: Mobile DNA 2015 6:18

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