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  1. Review

    Roles for retrotransposon insertions in human disease

    Over evolutionary time, the dynamic nature of a genome is driven, in part, by the activity of transposable elements (TE) such as retrotransposons. On a shorter time scale it has been established that new TE in...

    Dustin C. Hancks and Haig H. Kazazian Jr.

    Mobile DNA 2016 7:9

    Published on: 6 May 2016

  2. Research

    Genomic analysis of mouse VL30 retrotransposons

    Retrotransposons are mobile elements that have a high impact on shaping the mammalian genomes. Since the availability of whole genomes, genomic analyses have provided novel insights into retrotransposon biolog...

    Georgios Markopoulos, Dimitrios Noutsopoulos, Stefania Mantziou, Demetrios Gerogiannis, Soteroula Thrasyvoulou, Georgios Vartholomatos, Evangelos Kolettas and Theodore Tzavaras

    Mobile DNA 2016 7:10

    Published on: 6 May 2016

  3. Research

    The endonuclease domain of the LINE-1 ORF2 protein can tolerate multiple mutations

    Approximately 17 % of the human genome is comprised of the Long INterspersed Element-1 (LINE-1 or L1) retrotransposon, the only currently active autonomous family of retroelements. Though L1 elements have helped ...

    Kristine J. Kines, Mark Sokolowski, Dawn L. deHaro, Claiborne M. Christian, Melody Baddoo, Madison E. Smither and Victoria P. Belancio

    Mobile DNA 2016 7:8

    Published on: 19 April 2016

  4. Methodology

    Alu SINE analyses of 3,000-year-old human skeletal remains: a pilot study

    As Short Interspersed Elements (SINEs), human-specific Alu elements can be used for population genetic studies. Very recent inserts are polymorphic within and between human populations. In a sample of 30 elements...

    Maximilian Kothe, Verena Seidenberg, Susanne Hummel and Oliver Piskurek

    Mobile DNA 2016 7:7

    Published on: 18 April 2016

  5. Research

    Active recombinant Tol2 transposase for gene transfer and gene discovery applications

    The revolutionary concept of “jumping genes” was conceived by McClintock in the late 1940s while studying the Activator/Dissociation (Ac/Ds) system in maize. Transposable elements (TEs) represent the most abundan...

    Jun Ni, Kirk J. Wangensteen, David Nelsen, Darius Balciunas, Kimberly J. Skuster, Mark D. Urban and Stephen C. Ekker

    Mobile DNA 2016 7:6

    Published on: 31 March 2016

  6. Research

    Ribosomal protein and biogenesis factors affect multiple steps during movement of the Saccharomyces cerevisiae Ty1 retrotransposon

    A large number of Saccharomyces cerevisiae cellular factors modulate the movement of the retrovirus-like transposon Ty1. Surprisingly, a significant number of chromosomal genes required for Ty1 transposition enco...

    Susmitha Suresh, Hyo Won Ahn, Kartikeya Joshi, Arun Dakshinamurthy, Arun Kannanganat, David J. Garfinkel and Philip J. Farabaugh

    Mobile DNA 2015 6:22

    Published on: 8 December 2015

    The Erratum to this article has been published in Mobile DNA 2016 7:5

  7. Research

    Transposable element polymorphisms recapitulate human evolution

    The human genome contains several active families of transposable elements (TE): Alu, L1 and SVA. Germline transposition of these elements can lead to polymorphic TE (polyTE) loci that differ between individua...

    Lavanya Rishishwar, Carlos E. Tellez Villa and I. King Jordan

    Mobile DNA 2015 6:21

    Published on: 16 November 2015

  8. Meeting Report

    First international workshop on human endogenous retroviruses and diseases, HERVs & disease 2015

    The First International Scientific Conference on Human Endogenous Retroviruses (HERVs) and Disease, Lyon-France, May 26-27th 2015, brought together scientific and medical specialists from around the world investi...

    Avindra Nath, Patrick Küry, Guilherme Sciascia do Olival, Antonina Dolei, Håkan Karlsson, Laurent Groc, Marion Schneider, John Kriesel, Jean-Louis Touraine, François Mallet, Patrice N. Marche, Frederick Arnaud, Cédric Feschotte and Hervé Perron

    Mobile DNA 2015 6:20

    Published on: 15 October 2015

  9. Research

    Identification and characterization of a minisatellite contained within a novel miniature inverted-repeat transposable element (MITE) of Porphyromonas gingivalis

    Repetitive regions of DNA and transposable elements have been found to constitute large percentages of eukaryotic and prokaryotic genomes. Such elements are known to be involved in transcriptional regulation, ...

    Brian A. Klein, Tsute Chen, Jodie C. Scott, Andrea L. Koenigsberg, Margaret J. Duncan and Linden T. Hu

    Mobile DNA 2015 6:18

    Published on: 6 October 2015

  10. Research

    Comparative paleovirological analysis of crustaceans identifies multiple widespread viral groups

    The discovery of many fragments of viral genomes integrated in the genome of their eukaryotic host (endogenous viral elements; EVEs) has recently opened new avenues to further our understanding of viral evolut...

    Gabriel Metegnier, Thomas Becking, Mohamed Amine Chebbi, Isabelle Giraud, Bouziane Moumen, Sarah Schaack, Richard Cordaux and Clément Gilbert

    Mobile DNA 2015 6:16

    Published on: 16 September 2015

  11. Research

    Precise repair of mPing excision sites is facilitated by target site duplication derived microhomology

    A key difference between the Tourist and Stowaway families of miniature inverted repeat transposable elements (MITEs) is the manner in which their excision alters the genome. Upon excision, Stowaway-like MITEs an...

    David M. Gilbert, M. Catherine Bridges, Ashley E. Strother, Courtney E. Burckhalter, James M. Burnette III and C. Nathan Hancock

    Mobile DNA 2015 6:15

    Published on: 7 September 2015

  12. Research

    A host factor supports retrotransposition of the TRE5-A population in Dictyostelium cells by suppressing an Argonaute protein

    In the compact and haploid genome of Dictyostelium discoideum control of transposon activity is of particular importance to maintain viability. The non-long terminal repeat retrotransposon TRE5-A amplifies contin...

    Anika Schmith, Thomas Spaller, Friedemann Gaube, Åsa Fransson, Benjamin Boesler, Sandeep Ojha, Wolfgang Nellen, Christian Hammann, Fredrik Söderbom and Thomas Winckler

    Mobile DNA 2015 6:14

    Published on: 3 September 2015

  13. Commentary

    A call for benchmarking transposable element annotation methods

    DNA derived from transposable elements (TEs) constitutes large parts of the genomes of complex eukaryotes, with major impacts not only on genomic research but also on how organisms evolve and function. Althoug...

    Douglas R. Hoen, Glenn Hickey, Guillaume Bourque, Josep Casacuberta, Richard Cordaux, Cédric Feschotte, Anna-Sophie Fiston-Lavier, Aurélie Hua-Van, Robert Hubley, Aurélie Kapusta, Emmanuelle Lerat, Florian Maumus, David D. Pollock, Hadi Quesneville, Arian Smit, Travis J. Wheeler…

    Mobile DNA 2015 6:13

    Published on: 4 August 2015

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