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  1. Content type: Review

    Retrotransposons are transposable elements (TEs) capable of “jumping” in germ, embryonic and tumor cells and, as is now clearly established, in the neuronal lineage. Mosaic TE insertions form part of a broader...

    Authors: Geoffrey J. Faulkner and Victor Billon

    Citation: Mobile DNA 2018 9:22

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  2. Content type: Meeting report

    The Mobile Genetic Elements and Genome Plasticity conference was hosted by Keystone Symposia in Santa Fe, NM USA, February 11–15, 2018. The organizers were Marlene Belfort, Evan Eichler, Henry Levin and Lynne ...

    Authors: John M. Abrams, Irina R. Arkhipova, Marlene Belfort, Jef D. Boeke, M. Joan Curcio, Geoffrey J. Faulkner, John L. Goodier, Ruth Lehmann and Henry L. Levin

    Citation: Mobile DNA 2018 9:21

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  4. Content type: Research

    Transposable elements (TEs) are common and often present with high copy numbers in cellular genomes. Unlike in cellular organisms, TEs were previously thought to be either rare or absent in viruses. Almost all...

    Authors: Hua-Hao Zhang, Qiu-Zhong Zhou, Ping-Lan Wang, Xiao-Min Xiong, Andrea Luchetti, Didier Raoult, Anthony Levasseur, Sebastien Santini, Chantal Abergel, Matthieu Legendre, Jean-Michel Drezen, Catherine Béliveau, Michel Cusson, Shen-Hua Jiang, Hai-Ou Bao, Cheng Sun…

    Citation: Mobile DNA 2018 9:19

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  8. Content type: Commentary

    In the course of analyzing whole-genome data, it is common practice to mask or filter out repetitive regions of a genome, such as transposable elements and endogenous retroviruses, in order to focus only on ge...

    Authors: R. Keith Slotkin

    Citation: Mobile DNA 2018 9:15

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  10. Content type: Research

    Since the completion of the human genome project, the diversity of genome sequencing data produced for non-human primates has increased exponentially. Papio baboons are well-established biological models for stud...

    Authors: Vallmer E. Jordan, Jerilyn A. Walker, Thomas O. Beckstrom, Cody J. Steely, Cullen L. McDaniel, Corey P. St. Romain, Kim C. Worley, Jane Phillips-Conroy, Clifford J. Jolly, Jeffrey Rogers, Miriam K. Konkel and Mark A. Batzer

    Citation: Mobile DNA 2018 9:13

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  11. Content type: Research

    LINE-1 (L1) is the dominant autonomously replicating non-LTR retrotransposon in mammals. Although our knowledge of L1 evolution across the tree of life has considerably improved in recent years, what we know o...

    Authors: Akash Sookdeo, Crystal M. Hepp and Stéphane Boissinot

    Citation: Mobile DNA 2018 9:12

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  12. Content type: Research

    The restriction factor SAMHD1 regulates intracellular nucleotide level by degrading dNTPs and blocks the replication of retroviruses and DNA viruses in non-cycling cells, like macrophages or dendritic cells. I...

    Authors: Alexandra Herrmann, Sabine Wittmann, Dominique Thomas, Caitlin N. Shepard, Baek Kim, Nerea Ferreirós and Thomas Gramberg

    Citation: Mobile DNA 2018 9:11

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    The Correction to this article has been published in Mobile DNA 2018 9:16

  13. Content type: Research

    Alu elements are primate-specific retroposons that mobilize using the enzymatic machinery of L1 s. The recently completed baboon genome project found that the mobilization rate of Alu elements is higher than in t...

    Authors: Cody J. Steely, Jasmine N. Baker, Jerilyn A. Walker, Charles D. Loupe III and Mark A. Batzer

    Citation: Mobile DNA 2018 9:10

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  14. Content type: Research

    The evolution of Alu elements has been ongoing in primate lineages and Alu insertion polymorphisms are widely used in phylogenetic and population genetics studies. Alu subfamilies in the squirrel monkey (Saimiri)...

    Authors: Jasmine N. Baker, Jerilyn A. Walker, Michael W. Denham, Charles D. Loupe III and Mark A. Batzer

    Citation: Mobile DNA 2018 9:9

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  16. Content type: Research

    P-element transposition in the genome causes P-M hybrid dysgenesis in Drosophila melanogaster. Maternally deposited piRNAs suppress P-element transposition in the progeny, linking them to P-M phenotypes; however,...

    Authors: Keiko Tsuji Wakisaka, Kenji Ichiyanagi, Seiko Ohno and Masanobu Itoh

    Citation: Mobile DNA 2018 9:7

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  18. Content type: Research

    The genome of the gastric pathogen Helicobacter pylori is characterised by considerable variation of both gene sequence and content, much of which is contained within three large genomic islands comprising the ca...

    Authors: Robin M. Delahay, Nicola J. Croxall and Amberley D. Stephens

    Citation: Mobile DNA 2018 9:5

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  19. Content type: Research

    Inteins are mobile, self-splicing sequences that interrupt proteins and occur across all three domains of life. Scrutiny of the intein landscape in prokaryotes led to the hypothesis that some inteins are funct...

    Authors: Cathleen M. Green, Olga Novikova and Marlene Belfort

    Citation: Mobile DNA 2018 9:4

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  22. Content type: Research

    Long Interspersed Nuclear Element-1 (LINE-1) is an autonomous retrotransposon that generates new genomic insertions through the retrotransposition of a RNA intermediate. Expression of LINE-1 is tightly repress...

    Authors: Erica M. Briggs, Susan Ha, Paolo Mita, Gregory Brittingham, Ilaria Sciamanna, Corrado Spadafora and Susan K. Logan

    Citation: Mobile DNA 2018 9:1

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  23. Content type: Research

    While transposable elements (TEs) comprise the bulk of plant genomic DNA, how they contribute to genome structure and organization is still poorly understood. Especially in large genomes where TEs make the maj...

    Authors: Thomas Wicker, Alan H. Schulman, Jaakko Tanskanen, Manuel Spannagl, Sven Twardziok, Martin Mascher, Nathan M. Springer, Qing Li, Robbie Waugh, Chengdao Li, Guoping Zhang, Nils Stein, Klaus F. X. Mayer and Heidrun Gundlach

    Citation: Mobile DNA 2017 8:22

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  24. Content type: Research

    Passeriformes (“perching birds” or passerines) make up more than half of all extant bird species. The genome of the zebra finch, a passerine model organism for vocal learning, was noted previously to contain t...

    Authors: Alexander Suh, Sandra Bachg, Stephen Donnellan, Leo Joseph, Jürgen Brosius, Jan Ole Kriegs and Jürgen Schmitz

    Citation: Mobile DNA 2017 8:21

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  25. Content type: Research

    Intracisternal A particle (IAP) is one of the most transpositionally active retrotransposons in the mouse genome, but its expression varies between cell types. This variation is believed to arise from differen...

    Authors: Ken-ichi Shimosuga, Kei Fukuda, Hiroyuki Sasaki and Kenji Ichiyanagi

    Citation: Mobile DNA 2017 8:20

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  28. Content type: Research

    Recent reports indicate that retrotransposons – a type of mobile DNA – can contribute to neuronal genetic diversity in mammals. Retrotransposons are genetic elements that mobilize via an RNA intermediate by a ...

    Authors: Debpali Sur, Raj Kishor Kustwar, Savita Budania, Anita Mahadevan, Dustin C. Hancks, Vijay Yadav, S. K. Shankar and Prabhat K. Mandal

    Citation: Mobile DNA 2017 8:17

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  29. Content type: Research

    R2 elements are a clade of early branching Long Interspersed Elements (LINEs). LINEs are retrotransposable elements whose replication can have profound effects on the genomes in which they reside. No crystal o...

    Authors: M. Murshida Mahbub, Saiful M. Chowdhury and Shawn M. Christensen

    Citation: Mobile DNA 2017 8:16

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  30. Content type: Research

    About half of the human genome is constituted of transposable elements, including human endogenous retroviruses (HERV). HERV sequences represent the 8% of our genetic material, deriving from exogenous infectio...

    Authors: Nicole Grandi, Marta Cadeddu, Maria Paola Pisano, Francesca Esposito, Jonas Blomberg and Enzo Tramontano

    Citation: Mobile DNA 2017 8:15

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  31. Content type: Research

    Long terminal repeat retrotransposons (LTR-RTs) are major components of plant genomes. Common LTR-RTs contain the palindromic dinucleotide 5′-‘TG’–‘CA’-3′ motif at the ends. Thus, further analyses of non-canon...

    Authors: Hao Yin, Xiao Wu, Dongqing Shi, Yangyang Chen, Kaijie Qi, Zhengqiang Ma and Shaoling Zhang

    Citation: Mobile DNA 2017 8:14

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  32. Content type: Research

    Transposition of P elements in the genome causes P–M hybrid dysgenesis in Drosophila melanogaster. For the P strain, the P–M phenotypes are associated with the ability to express a class of small RNAs, called piw...

    Authors: Keiko Tsuji Wakisaka, Kenji Ichiyanagi, Seiko Ohno and Masanobu Itoh

    Citation: Mobile DNA 2017 8:13

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  34. Content type: Research

    Transposable elements (TEs) are highly abundant genomic parasites in eukaryote genomes. Although several genomes have been screened for TEs, so far very limited information is available regarding avian TEs and...

    Authors: Natasha Avila Bertocchi, Fabiano Pimentel Torres, Analía del Valle Garnero, Ricardo José Gunski and Gabriel Luz Wallau

    Citation: Mobile DNA 2017 8:11

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  36. Content type: Research

    Polymorphic human Alu elements are excellent tools for assessing population structure, and new retrotransposition events can contribute to disease. Next-generation sequencing has greatly increased the potential t...

    Authors: Julie Feusier, David J. Witherspoon, W. Scott Watkins, Clément Goubert, Thomas A. Sasani and Lynn B. Jorde

    Citation: Mobile DNA 2017 8:9

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  37. Content type: Research

    The ongoing mobilization of mammalian transposable elements (TEs) contributes to natural genetic variation. To survey the epigenetic control and expression of reporter genes inserted by L1 retrotransposition i...

    Authors: Manoj Kannan, Jingfeng Li, Sarah E. Fritz, Kathryn E. Husarek, Jonathan C. Sanford, Teresa L. Sullivan, Pawan Kumar Tiwary, Wenfeng An, Jef D. Boeke and David E. Symer

    Citation: Mobile DNA 2017 8:8

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  41. Content type: Research

    Retrotransposons comprise a ubiquitous and abundant class of eukaryotic transposable elements. All members of this class rely on reverse transcriptase activity to produce a DNA copy of the element from the RNA...

    Authors: Kirill Ustyantsev, Alexandr Blinov and Georgy Smyshlyaev

    Citation: Mobile DNA 2017 8:4

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  43. Content type: Research

    Transposable elements (TEs) comprise ~10% of the chicken (Gallus gallus) genome. The content of TEs is much lower than that of mammalian genomes, where TEs comprise around half of the genome. Endogenous retroviru...

    Authors: Jinmin Lee, Seyoung Mun, Dong Hee Kim, Chun-Sung Cho, Dong-Yep Oh and Kyudong Han

    Citation: Mobile DNA 2017 8:2

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  45. Content type: Research

    Helitrons are eukaryotic rolling circle transposable elements that can have a large impact on host genomes due to their copy-number and their ability to capture and copy genes and regulatory elements. They occ...

    Authors: Biju Vadakkemukadiyil Chellapan, Peter van Dam, Martijn Rep, Ben J. C. Cornelissen and Like Fokkens

    Citation: Mobile DNA 2016 7:27

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  47. Content type: Research

    Human endogenous retroviruses (HERVs) constitute 8% of the human genome and contribute substantially to the transcriptome. HERVs have been shown to generate RNAs that modulate host gene expression. However, ex...

    Authors: Felix Broecker, Roger Horton, Jochen Heinrich, Alexandra Franz, Michal-Ruth Schweiger, Hans Lehrach and Karin Moelling

    Citation: Mobile DNA 2016 7:25

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  48. Content type: Review

    Cancer arises from a series of genetic and epigenetic changes, which result in abnormal expression or mutational activation of oncogenes, as well as suppression/inactivation of tumor suppressor genes. Aberrant...

    Authors: Artem Babaian and Dixie L. Mager

    Citation: Mobile DNA 2016 7:24

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  50. Content type: Research

    LINE-1 (L1) retrotransposons are a notable endogenous source of mutagenesis in mammals. Notably, cancer cells can support unusual L1 retrotransposition and L1-associated sequence rearrangement mechanisms follo...

    Authors: Patricia E. Carreira, Adam D. Ewing, Guibo Li, Stephanie N. Schauer, Kyle R. Upton, Allister C. Fagg, Santiago Morell, Michaela Kindlova, Patricia Gerdes, Sandra R. Richardson, Bo Li, Daniel J. Gerhardt, Jun Wang, Paul M. Brennan and Geoffrey J. Faulkner

    Citation: Mobile DNA 2016 7:21

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Mobile DNA

ISSN: 1759-8753