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Postdoctoral position open in Eunice Kennedy Shriver National Institute of Child Health and Human Development (Bethesda, USA)

Position Title: Retrotransposon L1 and regulation of genomic repeats
Position Description: A postdoctoral position is available to study how human
retrotransposon L1 is restricted by factors that cause 5’ truncation. Projects also include
study of copy number regulation of rDNA repeat sequences.

Having a long-standing interest in how repeat sequences impact the biology of the host,
we study retrotransposons in fission yeast, HIV-1 integration in cell culture, 5’ truncation
of L1 insertions and copy number control of rDNA repeats. Further details and a list of
publications can be found at:
https://science.nichd.nih.gov/confluence/display/sete/Home

Interested candidates must have a Ph.D. and/or an M.D. and have a strong background in
molecular genetics. Skills in bioinformatics and nanopore sequencing are desirable. To
apply submit a cover letter, curriculum vitae, bibliography, and names of three references
to:
Dr. Henry Levin
Eunice Kennedy Shriver National Institute of Child Health and Human Development
National Institutes of Health
Bld 49, room 1A35A
Bethesda, MD, 20892
E-mail: henry_levin@nih.gov
Employer Name: Eunice Kennedy Shriver National Institute of Child Health and Human
Development
The NIH is dedicated to building a diverse community in its training and employment
programs.

Postdoctoral position open in Bourc’his lab, Institut Curie (Paris, France)
We are looking for an enthusiastic and highly motivated candidate to join the Bourc’his lab, Institut Curie (Paris, France), to study the intercations between retrotransposons and host genomes, in the context of germline development and early embryogenesis. Using the mouse model, we are broadly interested in identifying the defense strategies developed by mammalian genomes to prevent retrotransposons from interfering with reproductive fitness, and in addressing the impact—deleterious or beneficial—of retrotransposons on genome organization and function. We use a combination of mouse genetics, molecular and cellular biology, genome-wide screens, genomic and transcriptomic profiling by short-read (including single cell) and long-read sequencing followed by adapted computational methodologies for the study of repeated transposable elements. Among our latest achievements are the identification of m6A RNA methylation as a signal for retrotransposon degradation (Chelmicki et al., Nature 2021), the role played by retrotransposons in the evolution of DNA methylation enzymes (Molaro et al., Mol Biol Evol 2020; Barau et al. Science 2016) and the short- and long- term roles of germline DNA methylation on fertility and the programming of phenotypes at the next generation (Dura et al., bioRxiv 2021; Greenberg et al., Nature Genetics 2017).

Our team is located in the Department of Genetics and Developmental Biology of the Institut Curie (in the center of Paris), a premier scientific institution in the European union, which offers state-of-the-art core facilities and platforms in a highly dynamic, multi-cultural and inclusive environment.  

Requirements

Good PhD track record Strong background in genetics, molecular biology, cellular biologyAutonomy and ability to drive a projectKnowledge of transposon biology: desirable but not essentialPrevious experience with the mouse model (in vivo and cultured cells): asset but not essentialBioinformatic expertise: asset but not essentialGood level in spoken and written English (French not required)

Offer
Starting date: anytime

Funding: 18 month-contract, renewal once. The salary will follow the Institut Curie guidelines for postdoctoral fellowships. The candidate will be expected to also apply for independent funding; assistance and mentoring will be provided throughout the application process.

The candidate will be strongly supported for career development and will benefit from technical and soft skill courses provided by the Institut Curie Training Unit. Opportunities for mentoring students will be given.  

Application details
We are reviewing applications as they arrive; candidates are encouraged to submit their applications as soon as possible.

Please send to Deborah.Bourchis@curie.fr:

- curriculum vitae, including list of publications (preprints included) and communications
- cover letter outlining past research experience, motivation to join our group and career goals
- names/contact information of two references