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Postdoctoral Position at the Wadsworth Center
Laboratories of Joan Curcio and Alexey Khodjakov
A 2.5 year NSF-funded postdoctoral position is available to investigate the effects of the Ty1 retrovirus-like transposon on asymmetric cell division in Saccharomyces cerevisiae. The Curcio lab has long been interested in the relationship between retrovirus-like transposons and their eukaryotic hosts. Our recent work explores host control of Ty1 virus-like particle (VLP) assembly. Ty1 RNA is translated and packaged into VLPs in a cytoplasmic focus known as the retrosome. In collaboration with the Khodjakov lab, we have discovered that retrosome formation is asymmetrically restricted to mother cells; moreover, conditions that promote retrosome formation disrupt the age-dependent segregation of spindle pole bodies (SPBs, yeast centrosomes), a prerequisite for spindle alignment and faithful chromosome segregation. Quantitative fluorescence imaging will be used to understand how retrosome formation impacts SPB inheritance, spindle alignment, chromosome segregation and lifespan. Genetic, biochemical and quantitative imaging approaches will be combined to explore the crosstalk between the Ty1 Gag protein and SPB components as well as signaling networks that coordinately regulate retrosome formation and SPB inheritance.
Interested candidates must have a PhD or MD, strong writing, oral communication and quantitative skills, and a background in cell biology and/or genetics. Experience in retrovirus or transposon biology is a plus. Applicants should submit a cover letter, curriculum vitae, a one-page description of their research experience and goals, and the names of three or more references to joan.curcio@health.NY.gov or to:
Dr. Joan Curcio
New York State Department of Health
Center for Medical Sciences
P.O. Box 22002
Albany NY 12201-2002
(Posted October 25, 2018)
Post-Doc Associates at Danforth Center
The Slotkin laboratory is currently seeking two organized and motivated researchers to add our group. The new postdocs will investigate how transposable elements and transgenes are targeted for epigenetic silencing using cutting-edge techniques including: single-molecule long-read sequencing, whole genome methylome analysis, and small RNA deep sequencing. Both wet-bench and computational informaticists will be considered, as well as any combination of these skill-sets. Candidates with experience in epigenetics, epigenomics and/or transposable elements are highly encouraged to apply. For more information about our research program, please visit the lab page. Learn more about the position here.
PhD Studentship at Aberdeen University
This studentship aims to gain a better understanding of fundamental processes of genome evolution that remain poorly understood. The project will investigate the role of transposable elements (TEs) in evolutionary diversification following whole genome duplication (WGD), using salmonid fishes as an ideal study system due to the presence of an ancestral WGD event that has had a major impact on genome evolution and been linked with lineage diversification (e.g. Lien et al. 2016; Robertson et al. 2017). We will test the hypothesis that TEs have been instrumental agents in reshaping genetic and epigenetic evolution following WGD, promoting adaptation.
This PhD is embedded within a Norwegian research project ‘TRANSPOSE: Transposable elements as agents of genome evolution and adaptation following a recent whole genome duplication’. TRANSPOSE is a 5 year project and supervisor Macqueen is a collaborator. Position is open to UK/European applicants only. For application information, please follow the instructions on the posting here.
Postdoctoral Position at University of Texas-Austin
Postdoctoral position available for research projects investigating the mechanism of repair of phage Mu transposition and Flp recombination events by the E. coli / yeast replication machineries, respectively. This process will be explored both in vitro and in vivo using biochemical, biophysical and cell biological tools. The mechanism of Mu integration is similar to retroviruses, and we anticipate extending the studies to the repair of retroviral integration events in mammalian cells. The Flp studies have the potential for application in cancer therapy.
Applicants must have first-author publications in peer-reviewed journals and be highly motivated. A strong background in bacterial or yeast biology, DNA biochemistry, and molecular genetics is desired. Protein purification skills are a MUST. A basic understanding of programming and network analysis is a plus.
Austin, TX has been consistently ranked one of the best places to live in the United States. The University of Texas offers competitive benefits. Applicants should email their CV and list of three references to Rasika Harshey: email@example.com.
Postdoctoral Position at the NIH
Position Title: Genomic and mechanistic studies of transposable elements and HIV-1
Position Description: A postdoctoral position is available to study the mechanisms and impact of Long Terminal Repeat-retrotransposons and retroviruses. The LTR-retrotransposon Tf1 in the fission yeast Schizosaccharomyces pombe is structurally similar to retroviruses and uses mechanisms of reverse transcription and integration that are excellent models for retrovirus replication. Saturated profiles of integration sites revealed Tf1 inserts into the promoters of stress response genes. Current work focuses on how chromatin factors promote integration site selection. To identify common mechanisms of integration we generate large-scale datasets of HIV-1 integration in human cells and analyze genome-wide patterns of integration. Research is also conducted on other transposable elements to develop technology capable of generating genome-wide profiles of gene function. Further details and a list of publications can be found at:
Interested candidates must have a Ph.D. and/or an M.D. and have a strong background in molecular biology, genetics, or virology. Bioinformatic and programming skills will be of great benefit. To apply submit a cover letter, curriculum vitae, bibliography, and names of three references to:
Dr. Henry Levin
Eunice Kennedy Shriver National Institute of Child Health and Human Development
National Institutes of Health
Bld 49, room 1C32
Bethesda, MD, 20892
Employer Name: Eunice Kennedy Shriver National Institute of Child Health and Human Development
Position Location: Bethesda, MD.
The NIH is dedicated to building a diverse community in its training and employment programs.
Posted: 16th March 2017.
Bioinformatics postdoctoral position at the Evolutionary and Functional Genomics LAB, Institute of Evolutionary Biology (CSIC-UPF), Parc de Recerca Biomèdica de Barcelona, Spain.
Contact their lab for more information.