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  1. LINE-1s, Alus and SVAs are the only retrotransposition competent elements in humans. Their mobilization followed by insertional mutagenesis is often linked to disease. Apart from these rare integration events,...

    Authors: Simanti Das, Amanda E. Jones and John M. Abrams
    Citation: Mobile DNA 2022 13:30
    Content type: Research Published on:

  3. Transposable elements (TEs) are selfish DNA sequences capable of moving and amplifying at the expense of host cells. Despite this, an increasing number of studies have revealed that TE proteins are important c...

    Authors: Dragomira N. Markova, Fatema B. Ruma, Claudio Casola, Ayda Mirsalehi and Esther Betrán
    Citation: Mobile DNA 2022 13:28
    Content type: Research Published on:

  5. Transposable elements are ubiquitous and play a fundamental role in shaping genomes during evolution. Since excessive transposition can be mutagenic, mechanisms exist in the cells to keep these mobile elements...

    Authors: Anastasia Barkova, Indranil Adhya, Christine Conesa, Amna Asif-Laidin, Amandine Bonnet, Elise Rabut, Carine Chagneau, Pascale Lesage and Joël Acker
    Citation: Mobile DNA 2022 13:26
    Content type: Research Published on:

  6. Krüppel Associated Box-containing Zinc Finger Proteins (KRAB-ZFPs), representing the largest superfamily of transcription factors in mammals, are predicted to primarily target and repress transposable elements...

    Authors: Yang Zhang, Fei He, Yanning Zhang, Qian Dai, Qintong Li, Jing Nan, Ruidong Miao and Bo Cheng
    Citation: Mobile DNA 2022 13:25
    Content type: Research Published on:

  8. Mobile group I introns encode homing endonucleases that confer intron mobility initiated by a double-strand break in the intron-lacking allele at the site of insertion. Nuclear ribosomal DNA of some fungi and ...

    Authors: Kjersti Lian, Betty M. N. Furulund, Anders A. Tveita, Peik Haugen and Steinar D. Johansen
    Citation: Mobile DNA 2022 13:23
    Content type: Research Published on:

  9. Bats are a major reservoir of zoonotic viruses, and there has been growing interest in characterizing bat-specific features of innate immunity and inflammation. Recent studies have revealed bat-specific adapta...

    Authors: Giulia Irene Maria Pasquesi, Conor J. Kelly, Andrea D. Ordonez and Edward B. Chuong
    Citation: Mobile DNA 2022 13:22
    Content type: Research Published on:

  10. Endogenous expression of L1 mRNA is the first step in an L1-initiated mutagenesis event. However, the contribution of individual cell types to patterns of organ-specific L1 mRNA expression remains poorly under...

    Authors: Emily C. Stow, Melody Baddoo, Alexis J. LaRosa, Dawn LaCoste, Prescott Deininger and Victoria Belancio
    Citation: Mobile DNA 2022 13:21
    Content type: Research Published on:

  12. ICEs are mobile genetic elements found integrated into bacterial chromosomes that can excise and be transferred to a new cell. They play an important role in horizontal gene transmission and carry accessory ge...

    Authors: Jéssica Catarine Silva de Assis, Osiel Silva Gonçalves, Alexia Suellen Fernandes, Marisa Vieira de Queiroz, Denise Mara Soares Bazzolli and Mateus Ferreira Santana
    Citation: Mobile DNA 2022 13:19
    Content type: Research Published on:

  13. Long terminal repeat retrotransposons (LTR-RTs) make up a considerable portion of plant genomes. New insertions of these active LTR-RTs modify gene structures and functions and play an important role in genome...

    Authors: Hyunjin Koo, Soomin Kim, Hyun-Seung Park, Sang-Ji Lee, Nam-Chon Paek, Jungnam Cho and Tae-Jin Yang
    Citation: Mobile DNA 2022 13:18
    Content type: Brief Report Published on:

  15. Transposable element (TE) transcription is a precursor to its mobilisation in host genomes. However, the characteristics of expressed TE loci, the identification of self-competent transposon loci contributing ...

    Authors: Ting-Hsuan Chen and Christopher Winefield
    Citation: Mobile DNA 2022 13:16
    Content type: Research Published on:

  17. Transposable elements (TEs) are major genomic components in most eukaryotic genomes and play an important role in genome evolution. However, despite their relevance the identification of TEs is not an easy tas...

    Authors: Matias Rodriguez and Wojciech Makałowski
    Citation: Mobile DNA 2022 13:14
    Content type: Software Published on:

  18. The internal promoter in L1 5’UTR is critical for autonomous L1 transcription and initiating retrotransposition. Unlike the human genome, which features one contemporarily active subfamily, four subfamilies (A...

    Authors: Lingqi Kong, Karabi Saha, Yuchi Hu, Jada N. Tschetter, Chase E. Habben, Leanne S. Whitmore, Changfeng Yao, Xijin Ge, Ping Ye, Simon J. Newkirk and Wenfeng An
    Citation: Mobile DNA 2022 13:13
    Content type: Research Published on:

  19. Whiteflies are agricultural pests that cause negative impacts globally to crop yields resulting at times in severe economic losses and food insecurity. The Bemisia tabaci whitefly species complex is the most dama...

    Authors: Juan Paolo A. Sicat, Paul Visendi, Steven O. Sewe, Sophie Bouvaine and Susan E. Seal
    Citation: Mobile DNA 2022 13:12
    Content type: Research Published on:

    The Correction to this article has been published in Mobile DNA 2022 13:17

  21. Type 1 long interspersed elements, or LINE-1, are the only retroelements that replicate autonomously in human cells. The retrotransposition process of LINE-1 can trigger the activation of the innate immune sys...

    Authors: Jiaxiu Yan, Yifei Zhao, Juan Du, Yu Wang, Shaohua Wang, Qing Wang, Xu Zhao, Wei Xu and Ke Zhao
    Citation: Mobile DNA 2022 13:10
    Content type: Research Published on:

  23. CACTA transposable elements (TEs) comprise one of the most abundant superfamilies of Class 2 (cut-and-paste) transposons. Over recent decades, CACTA elements were widely identified in species from the plant, f...

    Authors: Alexander Belyayev, Jiřina Josefiová, Michaela Jandová, Ruslan Kalendar, Václav Mahelka, Bohumil Mandák and Karol Krak
    Citation: Mobile DNA 2022 13:8
    Content type: Research Published on:

  24. In the study of transposable elements (TEs), the generation of a high confidence set of consensus sequences that represent the diversity of TEs found in a given genome is a key step in the path to investigate ...

    Authors: Clement Goubert, Rory J. Craig, Agustin F. Bilat, Valentina Peona, Aaron A. Vogan and Anna V. Protasio
    Citation: Mobile DNA 2022 13:7
    Content type: Methodology Published on:

    The Correction to this article has been published in Mobile DNA 2022 13:15

  27. Transposable element-embedded regulatory sequences (TEeRS) and their KRAB-containing zinc finger protein (KZFP) controllers are increasingly recognized as modulators of gene expression. We aim to characterize ...

    Authors: Alexandra Iouranova, Delphine Grun, Tamara Rossy, Julien Duc, Alexandre Coudray, Michael Imbeault, Jonas de Tribolet-Hardy, Priscilla Turelli, Alexandre Persat and Didier Trono
    Citation: Mobile DNA 2022 13:4
    Content type: Research Published on:

  28. The fifth Japanese meeting on host–transposon interactions, titled “Biological Function and Evolution through Interactions between Hosts and Transposable Elements (TEs),” was held online on August 26–27, 2021....

    Authors: Kenji Ichiyanagi and Kuniaki Saito
    Citation: Mobile DNA 2022 13:3
    Content type: Meeting Report Published on:

  29. The IS6 family of insertion sequences is a large but coherent group which was originally named to avoid confusion between a number of identical or nearly identical IS that were identified at about the same time a...

    Authors: Alessandro Varani, Susu He, Patricia Siguier, Karen Ross and Michael Chandler
    Citation: Mobile DNA 2022 13:2
    Content type: Correspondence Published on:

  31. Retrotransposons have been implicated as causes of Mendelian disease, but their role in autism spectrum disorder (ASD) has not been systematically defined, because they are only called with adequate sensitivit...

    Authors: Rebeca Borges-Monroy, Chong Chu, Caroline Dias, Jaejoon Choi, Soohyun Lee, Yue Gao, Taehwan Shin, Peter J. Park, Christopher A. Walsh and Eunjung Alice Lee
    Citation: Mobile DNA 2021 12:28
    Content type: Research Published on:

  32. The majority of structural variation in genomes is caused by insertions of transposable elements (TEs). In mammalian genomes, the main TE fraction is made up of autonomous and non-autonomous non-LTR retrotrans...

    Authors: Malte Petersen, Sven Winter, Raphael Coimbra, Menno J. de Jong, Vladimir V. Kapitonov and Maria A. Nilsson
    Citation: Mobile DNA 2021 12:27
    Content type: Research Published on:

  33. LINE-1 (Long Interspersed Nuclear Elements, L1) retrotransposons are the only autonomously active transposable elements in the human genome. The evolution of L1 retrotransposition rates and its implications fo...

    Authors: Sawsan Sami Wehbi and Heinrich zu Dohna
    Citation: Mobile DNA 2021 12:26
    Content type: Research Published on:

  34. Tn5253, a composite Integrative Conjugative Element (ICE) of Streptococcus pneumoniae carrying tet(M) and cat resistance determinants, was found to (i) integrate at specific 83-bp integration site (attB), (ii) pr...

    Authors: Francesco Santoro, Valeria Fox, Alessandra Romeo, Elisa Lazzeri, Gianni Pozzi and Francesco Iannelli
    Citation: Mobile DNA 2021 12:25
    Content type: Research Published on:

  35. With the expansion of high throughput sequencing, we now have access to a larger number of genome-wide studies analyzing the Transposable elements (TEs) composition in a wide variety of organisms. However, gen...

    Authors: Jonathan Filée, Sarah Farhat, Dominique Higuet, Laure Teysset, Dominique Marie, Camille Thomas-Bulle, Stephane Hourdez, Didier Jollivet and Eric Bonnivard
    Citation: Mobile DNA 2021 12:24
    Content type: Research Published on:

  36. The submandibular gland (SG) is a relatively simple organ formed by three cell types: acinar, myoepithelial, and an intricate network of duct-forming epithelial cells, that together fulfills several physiologi...

    Authors: Braulio Valdebenito-Maturana, Francisca Torres, Mónica Carrasco and Juan Carlos Tapia
    Citation: Mobile DNA 2021 12:23
    Content type: Short report Published on:

  37. Transposable elements (TEs) significantly contribute to shaping the diversity of the human genome, and lines of evidence suggest TEs as one of driving forces of human brain evolution. Existing computational ap...

    Authors: Yilan Wang, Boxun Zhao, Jaejoon Choi and Eunjung Alice Lee
    Citation: Mobile DNA 2021 12:22
    Content type: Review Published on:

  38. The autonomous retroelement Long Interspersed Element-1 (LINE-1) mobilizes though a copy and paste mechanism using an RNA intermediate (retrotransposition). Throughout human evolution, around 500,000 LINE-1 se...

    Authors: Erica M. Briggs, Paolo Mita, Xiaoji Sun, Susan Ha, Nikita Vasilyev, Zev R. Leopold, Evgeny Nudler, Jef D. Boeke and Susan K. Logan
    Citation: Mobile DNA 2021 12:21
    Content type: Research Published on:

  39. Toll-like receptors (TLRs) play important roles in building innate immune and inducing adaptive immune responses. Associations of the TLR genes polymorphisms with disease susceptibility, which are the basis of mo...

    Authors: XiaoYan Wang, Zixuan Chen, Eduard Murani, Enrico D’Alessandro, Yalong An, Cai Chen, Kui Li, Grazia Galeano, Klaus Wimmers and Chengyi Song
    Citation: Mobile DNA 2021 12:20
    Content type: Research Published on:

  42. Molecular markers based on retrotransposon insertion polymorphisms (RIPs) have been developed and are widely used in plants and animals. Short interspersed nuclear elements (SINEs) exert wide impacts on gene a...

    Authors: Cai Chen, Enrico D’Alessandro, Eduard Murani, Yao Zheng, Domenico Giosa, Naisu Yang, Xiaoyan Wang, Bo Gao, Kui Li, Klaus Wimmers and Chengyi Song
    Citation: Mobile DNA 2021 12:17
    Content type: Research Published on:

  43. Transposable elements (TEs) play powerful and varied evolutionary and functional roles, and are widespread in most eukaryotic genomes. Research into their unique biology has driven the creation of a large coll...

    Authors: Tyler A. Elliott, Tony Heitkam, Robert Hubley, Hadi Quesneville, Alexander Suh and Travis J. Wheeler
    Citation: Mobile DNA 2021 12:16
    Content type: Commentary Published on:

  45. Transposable elements (TEs) are repetitive sequences of viral origin that compose almost half of the human genome. These elements are tightly controlled within cells, and if activated, they can cause changes i...

    Authors: Mahboubeh R. Rostami and Martina Bradic
    Citation: Mobile DNA 2021 12:14
    Content type: Research Published on:

  47. Transposons are mobile genetic elements that colonize genomes and drive their plasticity in all organisms. DNA transposon-encoded transposases bind to the ends of their cognate transposons and catalyze their m...

    Authors: Marc Guérineau, Luiza Bessa, Séverine Moriau, Ewen Lescop, François Bontems, Nathalie Mathy, Eric Guittet, Julien Bischerour, Mireille Bétermier and Nelly Morellet
    Citation: Mobile DNA 2021 12:12
    Content type: Research Published on:

  49. SINEs comprise a significant part of animal genomes and are used to study the evolution of diverse taxa. Despite significant advances in SINE studies in vertebrates and higher eukaryotes in general, their own ...

    Authors: Nikita S. Vassetzky, Sergei A. Kosushkin, Vitaly I. Korchagin and Alexey P. Ryskov
    Citation: Mobile DNA 2021 12:10
    Content type: Research Published on:

  50. Group II introns are mobile retroelements, capable of invading new sites in DNA. They are self-splicing ribozymes that complex with an intron-encoded protein to form a ribonucleoprotein that targets DNA after ...

    Authors: Justin M. Waldern, Dorie Smith, Carol Lyn Piazza, E. Jake Bailey, Nicholas J. Schiraldi, Reza Nemati, Dan Fabris, Marlene Belfort and Olga Novikova
    Citation: Mobile DNA 2021 12:9
    Content type: Research Published on:
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Mobile DNA

ISSN: 1759-8753