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  1. Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease involving loss of motor neurons and having no known cure and uncertain etiology. Several studies have drawn connections between altered ...

    Authors: Gavin C. Pereira, Laura Sanchez, Paul M. Schaughency, Alejandro Rubio-Roldán, Jungbin A. Choi, Evarist Planet, Ranjan Batra, Priscilla Turelli, Didier Trono, Lyle W. Ostrow, John Ravits, Haig H. Kazazian, Sarah J. Wheelan, Sara R. Heras, Jens Mayer, Jose Luis García-Pérez…
    Citation: Mobile DNA 2018 9:35
    Content type: Research Published on:

  3. Similar to retro−/lenti- virus system, DNA transposons are useful tools for stable expression of exogenous genes in mammalian cells. Sleeping Beauty (SB) transposon has adopted for integrating genes into host ...

    Authors: Kaishun Hu, Yu Li, Wenjing Wu, Hengxing Chen, Zhen Chen, Yin Zhang, Yabin Guo and Dong Yin
    Citation: Mobile DNA 2018 9:33
    Content type: Research Published on:

    The Correction to this article has been published in Mobile DNA 2019 10:2

  4. Although repeat sequences constitute about 37% of carnivore genomes, the characteristics and distribution of repeat sequences among carnivore genomes have not been fully investigated. Based on the updated Repb...

    Authors: Changjun Peng, Lili Niu, Jiabo Deng, Jianqiu Yu, Xueyan Zhang, Chuang Zhou, Jinchuan Xing and Jing Li
    Citation: Mobile DNA 2018 9:32
    Content type: Research Published on:

  5. There is increasing evidence that the transpositional activity of retroelements (REs) is not limited to germ line cells, but often occurs in tumor and normal somatic cells. Somatic transpositions were found in...

    Authors: Alexander Y. Komkov, Anastasia A. Minervina, Gaiaz A. Nugmanov, Mariia V. Saliutina, Konstantin V. Khodosevich, Yuri B. Lebedev and Ilgar Z. Mamedov
    Citation: Mobile DNA 2018 9:31
    Content type: Methodology Published on:

  8. Transposable elements are biologically important components of eukaryote genomes. In particular, non-LTR retrotransposons (N-LTRrs) played a key role in shaping the human genome throughout evolution. In this s...

    Authors: Etienne Guichard, Valentina Peona, Guidantonio Malagoli Tagliazucchi, Lucia Abitante, Evelyn Jagoda, Margherita Musella, Marco Ricci, Alejandro Rubio-Roldán, Stefania Sarno, Donata Luiselli, Davide Pettener, Cristian Taccioli, Luca Pagani, Jose Luis Garcia-Perez and Alessio Boattini
    Citation: Mobile DNA 2018 9:28
    Content type: Research Published on:

  10. The antisense insertion of a canine short interspersed element (SINEC_Cf) in the pigmentation gene PMEL (or SILV) causes a coat pattern phenotype in dogs termed merle. Merle is a semi-dominant trait characterized...

    Authors: Sarah C. Murphy, Jacquelyn M. Evans, Kate L. Tsai and Leigh Anne Clark
    Citation: Mobile DNA 2018 9:26
    Content type: Research Published on:

  11. The field of small RNA is one of the most investigated research areas since they were shown to regulate transposable elements and gene expression and play essential roles in fundamental biological processes. S...

    Authors: Romain Pogorelcnik, Chantal Vaury, Pierre Pouchin, Silke Jensen and Emilie Brasset
    Citation: Mobile DNA 2018 9:25
    Content type: Software Published on:

  12. Homing endonuclease genes (HEGs) are widely distributed genetic elements in the mitochondrial genomes of a diversity of eukaryotes. Due to their ability to self-propagate within and between genomes, these elem...

    Authors: Zhun Yan, Zhimin Li, Li Yan, Yongting Yu, Yi Cheng, Jia Chen, Yunyun Liu, Chunsheng Gao, Liangbin Zeng, Xiangping Sun, Litao Guo and Jianping Xu
    Citation: Mobile DNA 2018 9:24
    Content type: Research Published on:

  13. The majority of Eukaryotic genomes are composed of a small portion of stable (non-mobile) genes and a large fraction of parasitic mobile elements such as transposable elements and endogenous viruses: the Mobil...

    Authors: Alexandre Freitas da Silva, Filipe Zimmer Dezordi, Elgion Lucio Silva Loreto and Gabriel Luz Wallau
    Citation: Mobile DNA 2018 9:23
    Content type: Research Published on:

  14. Retrotransposons are transposable elements (TEs) capable of “jumping” in germ, embryonic and tumor cells and, as is now clearly established, in the neuronal lineage. Mosaic TE insertions form part of a broader...

    Authors: Geoffrey J. Faulkner and Victor Billon
    Citation: Mobile DNA 2018 9:22
    Content type: Review Published on:

  15. The Mobile Genetic Elements and Genome Plasticity conference was hosted by Keystone Symposia in Santa Fe, NM USA, February 11–15, 2018. The organizers were Marlene Belfort, Evan Eichler, Henry Levin and Lynne ...

    Authors: John M. Abrams, Irina R. Arkhipova, Marlene Belfort, Jef D. Boeke, M. Joan Curcio, Geoffrey J. Faulkner, John L. Goodier, Ruth Lehmann and Henry L. Levin
    Citation: Mobile DNA 2018 9:21
    Content type: Meeting report Published on:

  17. Transposable elements (TEs) are common and often present with high copy numbers in cellular genomes. Unlike in cellular organisms, TEs were previously thought to be either rare or absent in viruses. Almost all...

    Authors: Hua-Hao Zhang, Qiu-Zhong Zhou, Ping-Lan Wang, Xiao-Min Xiong, Andrea Luchetti, Didier Raoult, Anthony Levasseur, Sebastien Santini, Chantal Abergel, Matthieu Legendre, Jean-Michel Drezen, Catherine Béliveau, Michel Cusson, Shen-Hua Jiang, Hai-Ou Bao, Cheng Sun…
    Citation: Mobile DNA 2018 9:19
    Content type: Research Published on:

  21. In the course of analyzing whole-genome data, it is common practice to mask or filter out repetitive regions of a genome, such as transposable elements and endogenous retroviruses, in order to focus only on ge...

    Authors: R. Keith Slotkin
    Citation: Mobile DNA 2018 9:15
    Content type: Commentary Published on:

  23. Since the completion of the human genome project, the diversity of genome sequencing data produced for non-human primates has increased exponentially. Papio baboons are well-established biological models for stud...

    Authors: Vallmer E. Jordan, Jerilyn A. Walker, Thomas O. Beckstrom, Cody J. Steely, Cullen L. McDaniel, Corey P. St. Romain, Kim C. Worley, Jane Phillips-Conroy, Clifford J. Jolly, Jeffrey Rogers, Miriam K. Konkel and Mark A. Batzer
    Citation: Mobile DNA 2018 9:13
    Content type: Research Published on:

  24. LINE-1 (L1) is the dominant autonomously replicating non-LTR retrotransposon in mammals. Although our knowledge of L1 evolution across the tree of life has considerably improved in recent years, what we know o...

    Authors: Akash Sookdeo, Crystal M. Hepp and Stéphane Boissinot
    Citation: Mobile DNA 2018 9:12
    Content type: Research Published on:

  25. The restriction factor SAMHD1 regulates intracellular nucleotide level by degrading dNTPs and blocks the replication of retroviruses and DNA viruses in non-cycling cells, like macrophages or dendritic cells. I...

    Authors: Alexandra Herrmann, Sabine Wittmann, Dominique Thomas, Caitlin N. Shepard, Baek Kim, Nerea Ferreirós and Thomas Gramberg
    Citation: Mobile DNA 2018 9:11
    Content type: Research Published on:

    The Correction to this article has been published in Mobile DNA 2018 9:16

  26. Alu elements are primate-specific retroposons that mobilize using the enzymatic machinery of L1 s. The recently completed baboon genome project found that the mobilization rate of Alu elements is higher than in t...

    Authors: Cody J. Steely, Jasmine N. Baker, Jerilyn A. Walker, Charles D. Loupe III and Mark A. Batzer
    Citation: Mobile DNA 2018 9:10
    Content type: Research Published on:

  27. The evolution of Alu elements has been ongoing in primate lineages and Alu insertion polymorphisms are widely used in phylogenetic and population genetics studies. Alu subfamilies in the squirrel monkey (Saimiri)...

    Authors: Jasmine N. Baker, Jerilyn A. Walker, Michael W. Denham, Charles D. Loupe III and Mark A. Batzer
    Citation: Mobile DNA 2018 9:9
    Content type: Research Published on:

  29. P-element transposition in the genome causes P-M hybrid dysgenesis in Drosophila melanogaster. Maternally deposited piRNAs suppress P-element transposition in the progeny, linking them to P-M phenotypes; however,...

    Authors: Keiko Tsuji Wakisaka, Kenji Ichiyanagi, Seiko Ohno and Masanobu Itoh
    Citation: Mobile DNA 2018 9:7
    Content type: Research Published on:

  31. The genome of the gastric pathogen Helicobacter pylori is characterised by considerable variation of both gene sequence and content, much of which is contained within three large genomic islands comprising the ca...

    Authors: Robin M. Delahay, Nicola J. Croxall and Amberley D. Stephens
    Citation: Mobile DNA 2018 9:5
    Content type: Research Published on:

  32. Inteins are mobile, self-splicing sequences that interrupt proteins and occur across all three domains of life. Scrutiny of the intein landscape in prokaryotes led to the hypothesis that some inteins are funct...

    Authors: Cathleen M. Green, Olga Novikova and Marlene Belfort
    Citation: Mobile DNA 2018 9:4
    Content type: Research Published on:

  35. Long Interspersed Nuclear Element-1 (LINE-1) is an autonomous retrotransposon that generates new genomic insertions through the retrotransposition of a RNA intermediate. Expression of LINE-1 is tightly repress...

    Authors: Erica M. Briggs, Susan Ha, Paolo Mita, Gregory Brittingham, Ilaria Sciamanna, Corrado Spadafora and Susan K. Logan
    Citation: Mobile DNA 2018 9:1
    Content type: Research Published on:

  36. While transposable elements (TEs) comprise the bulk of plant genomic DNA, how they contribute to genome structure and organization is still poorly understood. Especially in large genomes where TEs make the maj...

    Authors: Thomas Wicker, Alan H. Schulman, Jaakko Tanskanen, Manuel Spannagl, Sven Twardziok, Martin Mascher, Nathan M. Springer, Qing Li, Robbie Waugh, Chengdao Li, Guoping Zhang, Nils Stein, Klaus F. X. Mayer and Heidrun Gundlach
    Citation: Mobile DNA 2017 8:22
    Content type: Research Published on:

  37. Passeriformes (“perching birds” or passerines) make up more than half of all extant bird species. The genome of the zebra finch, a passerine model organism for vocal learning, was noted previously to contain t...

    Authors: Alexander Suh, Sandra Bachg, Stephen Donnellan, Leo Joseph, Jürgen Brosius, Jan Ole Kriegs and Jürgen Schmitz
    Citation: Mobile DNA 2017 8:21
    Content type: Research Published on:

  38. Intracisternal A particle (IAP) is one of the most transpositionally active retrotransposons in the mouse genome, but its expression varies between cell types. This variation is believed to arise from differen...

    Authors: Ken-ichi Shimosuga, Kei Fukuda, Hiroyuki Sasaki and Kenji Ichiyanagi
    Citation: Mobile DNA 2017 8:20
    Content type: Research Published on:

  41. Recent reports indicate that retrotransposons – a type of mobile DNA – can contribute to neuronal genetic diversity in mammals. Retrotransposons are genetic elements that mobilize via an RNA intermediate by a ...

    Authors: Debpali Sur, Raj Kishor Kustwar, Savita Budania, Anita Mahadevan, Dustin C. Hancks, Vijay Yadav, S. K. Shankar and Prabhat K. Mandal
    Citation: Mobile DNA 2017 8:17
    Content type: Research Published on:

  42. R2 elements are a clade of early branching Long Interspersed Elements (LINEs). LINEs are retrotransposable elements whose replication can have profound effects on the genomes in which they reside. No crystal o...

    Authors: M. Murshida Mahbub, Saiful M. Chowdhury and Shawn M. Christensen
    Citation: Mobile DNA 2017 8:16
    Content type: Research Published on:

  43. About half of the human genome is constituted of transposable elements, including human endogenous retroviruses (HERV). HERV sequences represent the 8% of our genetic material, deriving from exogenous infectio...

    Authors: Nicole Grandi, Marta Cadeddu, Maria Paola Pisano, Francesca Esposito, Jonas Blomberg and Enzo Tramontano
    Citation: Mobile DNA 2017 8:15
    Content type: Research Published on:

  44. Long terminal repeat retrotransposons (LTR-RTs) are major components of plant genomes. Common LTR-RTs contain the palindromic dinucleotide 5′-‘TG’–‘CA’-3′ motif at the ends. Thus, further analyses of non-canon...

    Authors: Hao Yin, Xiao Wu, Dongqing Shi, Yangyang Chen, Kaijie Qi, Zhengqiang Ma and Shaoling Zhang
    Citation: Mobile DNA 2017 8:14
    Content type: Research Published on:

  45. Transposition of P elements in the genome causes P–M hybrid dysgenesis in Drosophila melanogaster. For the P strain, the P–M phenotypes are associated with the ability to express a class of small RNAs, called piw...

    Authors: Keiko Tsuji Wakisaka, Kenji Ichiyanagi, Seiko Ohno and Masanobu Itoh
    Citation: Mobile DNA 2017 8:13
    Content type: Research Published on:

  47. Transposable elements (TEs) are highly abundant genomic parasites in eukaryote genomes. Although several genomes have been screened for TEs, so far very limited information is available regarding avian TEs and...

    Authors: Natasha Avila Bertocchi, Fabiano Pimentel Torres, Analía del Valle Garnero, Ricardo José Gunski and Gabriel Luz Wallau
    Citation: Mobile DNA 2017 8:11
    Content type: Research Published on:

  49. Polymorphic human Alu elements are excellent tools for assessing population structure, and new retrotransposition events can contribute to disease. Next-generation sequencing has greatly increased the potential t...

    Authors: Julie Feusier, David J. Witherspoon, W. Scott Watkins, Clément Goubert, Thomas A. Sasani and Lynn B. Jorde
    Citation: Mobile DNA 2017 8:9
    Content type: Research Published on:

  50. The ongoing mobilization of mammalian transposable elements (TEs) contributes to natural genetic variation. To survey the epigenetic control and expression of reporter genes inserted by L1 retrotransposition i...

    Authors: Manoj Kannan, Jingfeng Li, Sarah E. Fritz, Kathryn E. Husarek, Jonathan C. Sanford, Teresa L. Sullivan, Pawan Kumar Tiwary, Wenfeng An, Jef D. Boeke and David E. Symer
    Citation: Mobile DNA 2017 8:8
    Content type: Research Published on:
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ISSN: 1759-8753