Fig. 3

Expression of genes involved in epigenetic, transcriptional, or post-transcriptional regulation of L1 in neutrophils from SLE patients and healthy volunteers. A Schematic representation of the HUSH complex and the proteins involved in silencing L1 loci and expression of the indicated genes in HC and SLE patients segregated by disease activity. B Schematic representation of the NEXT complex that regulates L1 transcript decay and expression of the indicated genes in HC and SLE patients. C Schematic representation of the sirtuins that maintain inactive heterochromatin structure and anchor L1 loci to lamin A in the inner nuclear envelope and expression of SIRT6 and SIRT7 in HC and SLE patient neutrophils. D Other known regulators of L1 transcription and the expression these genes in HC and SLE neutrophils. Bars indicate mean ± standard deviation. * denotes p values < 0.05, ** p < 0.01, and *** p < 0.005