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Fig. 5 | Mobile DNA

Fig. 5

From: A unique eukaryotic lineage of composite-like DNA transposons encoding a DDD/E transposase and a His-Me finger homing endonuclease

Fig. 5

The models of propagation of KolobokP families. Red triangles represent LTDRs while red horizontal bars represent internal portions (INTs) of KolobokP. Scissors indicate His-Me finger nucleases. a Unequal crossover: the unequal crossover between the LTDRs on the sister chromatids results in the generation of a multimer and a solo LTDR. b Recombination may excise an extrachromosomal circular DNA composed of one LTDR and one INT. It would be integrated into a solo LTDR to generate a full-length copy (b1) or a full-length KolobokP copy to generate a multimer (b2). c During the DNA replication, the His-Me finger nuclease cleaves one DNA inside of an LTDR farther from the replication fork. If the LTDR closer to the replication fork is used by chance as a template, one LTDR-INT portion is duplicated (c1). If the LTDR farther from the replication fork is used as a template, the original KolobokP insertion is reinstated (c2)

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Mobile DNA

ISSN: 1759-8753