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Fig. 1 | Mobile DNA

Fig. 1

From: Exploration of the regulatory relationship between KRAB-Zfp clusters and their target transposable elements via a gene editing strategy at the cluster specific linker-associated sequences by CRISPR-Cas9

Fig. 1

Analyses of the genomewide distribution, the evolutionary relationship, and the properties of ZnF usage in mouse KRAB-Zfp genes. A A circular genomic map displays the distribution of all KRAB-Zfp genes across the mouse genome. The width of each purple bar positively correlates to the number of KRAB-Zfp genes in a cluster. B A phylogenetic tree demonstrates the genetic distance among all the KRAB-Zfp genes located within KRAB-Zfp clusters 3 and 5. Bootstrap is a computer system function, representing the reliability of the branches of an evolutionary tree, ranging from 0 to 1. The larger the bootstrap value, the more reliable the branches of the evolutionary tree are. C Probability heatmap of the composition of ZnFs for KRAB-ZFPs in clusters 3, 4, and 5, including their identity and the frequency of occurrence. The identity of a ZnF is designated by its unique fingerprint (the amino acid triplets), see Fig. 3A for more details. Each square represents a unique type of ZnF/fingerprint and the intensity of the red color correlates to its frequency of occurrence in the corresponding KRAB-ZFP labeled on the right

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Mobile DNA

ISSN: 1759-8753