Fig. 7

Analyses of RNA-Seq datasets for TE expression. a The percentage of retrotransposon reads among total mappable reads (TEs and genes) in the SRP064478 and GSE76220 RNA-Seq datasets. Significance was determined by Student's t-test. b The percentage of reads originating from retrotransposons among total mappable reads in cerebellum (left) and frontal cortex (right) samples of the GSE67196 dataset. c MDS plots of the GSE67196 dataset for TEs of C9ALS (blue), sALS (green), and control (red) samples. Samples are consecutively numbered for each group. d MDS plot of the NeuroLINCS SRP098831 dataset for TEs of C9ALS (blue), SMA (green), and control (red) samples (left). Individual patient samples are numbered consecutively and each replicate is given the same number. Discrete clustering of C9ALS samples is evident. Right: the percentage of retrotransposon reads among total mappable reads for C9ALS vs control samples of the NeuroLINCS dataset