Identification of a novel HERV-K(HML10): comprehensive characterization and comparative analysis in non-human primates provide insights about HML10 proviruses structure and diffusion

Table 2 HML10 sequences estimated time of integration

	LTR vs LTR	LTR vs consensus	gag vs consensus	pol vs consensus ^a	env vs consensus ^b	Average	O.C.A. ^c
1p36.13	14.1	21.0	22.5	no pol (62 nt only)	31.9	22.4	rhesus
1p22.2	no 5′ and 3’LTRs	no 5′ and 3’LTRs	no gag	no pol	45.0	45.0	rhesus
1q22	14.7	44.1	35.7	28.9	32.7	31.2	rhesus
6p22.1	12.7	36.5	43.0	18.9	32.8	28.8	rhesus
6p21.33a	22.9	18.0	25.2	21.3	21.3	21.7	rhesus^d
6p21.33b	22.9	18.0	25.2	21.3	21.3	21.7	orangutan^d
6q22.31	17.2	38.8	38.9	44.8	35.1	35.0	rhesus
19p13.2	no 5′ and 3’LTRs	no 5′ and 3’LTRs	^e	20.8	no env (48 nt only)	20.8	rhesus
19q13.41	no 3’LTR	46.0	37.4	27.2	45.9	39.1	rhesus
Yq11.221	20.8	45.2	41.5	30.4	44.7	36.5	rhesus
Average	17.9	33.5	33.7	26.7	34.5	28,58

^apartial sequence: nucleotides 1277–2571 in LTR14-HERVKC4-LTR14
^bpartial sequence: nucleotides 4103–5810 in LTR14-HERVKC4-LTR14
^cOldest Common Ancestor
^dProvirus loss in various intermediate species: chimpanzee, gorilla, orangutan and gibbon (6p21.33a); chimpanzee, gorilla, gibbon and rhesus (6p21.33b)
^esequence showing an highly divergent gag sequence, giving an estimated T of 165,7 that was not taken into account for the final T calculation

ISSN: 1759-8753