Fig. 1

Phylogenetic tree and structure of MULEs in Ae. aegypti. Neighbor-joining tree generated from a multiple alignment of 141 conceptually translated catalytic domains from transposase proteins with bootstrap values calculated from 1000 replicates. For element structures: TIRs are black triangles, exons are black boxes, DDE domains are blue boxes, introns are lines connecting boxes, colored lines indicate within family identity of noncoding regions, other TE insertions are gray triangles above elements, and dashed lines are missing sequences caused by gaps, deletions or large insertions. The maize MuDR transposase is used as an outgroup. The Ae. aegypti Mutator transposases are classified into 5 major lineages a–e