Fig. 3
From: Endogenous retroviral promoter exaptation in human cancer
Gene models of select lncRNAs initiating within LTRs that are involved in oncogenesis. a A solitary LTR12C element initiates SChLAP1, a long inter-genic non-coding RNA. b The 5’ LTR7 of a full-length HERVH element initiates the lncRNA ROR, with an exon partially incorporating internal ERV sequence. c The HOST2 lncRNA is completely derived from components of a Harlequin (or HERV-E) endogenous retrovirus and its flanking LTR2B. d Anti-sense to the AFAP1 gene, a THE1A LTR initiates transcription of the lncRNA AFAP1-AS1. The second exon of AFAP1-AS1 overlaps exons 14–16 of AFAP1, possibly leading to RNA interference of the gene