Fig. 3

Distribution of TE insertions across the NCI-60 panel. a. Individual insertions are arrayed in order of frequency horizontally, and cell lines are arrayed vertically. Yellow denotes presence of insertion; blue denotes absence. LINE-1 are on the upper plot, and Alu are on the lower. Cell types are listed for the lower panel, and the ordering is the same in the upper panel. b. The density plot shows proportions of insertions against the numbers of cell lines containing an insertion. For both Alu (red) and LINE-1 (green), there is a bimodal distribution. The leftmost density reflects a large number of polymorphic insertions with low allele frequencies and (for LINE-1 singletons) somatically acquired insertions. The rightmost increase in density shows common variants or fixed insertions present in most or all cell lines