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Fig. 1 | Mobile DNA

Fig. 1

From: Spotting the enemy within: Targeted silencing of foreign DNA in mammalian genomes by the Krüppel-associated box zinc finger protein family

Fig. 1

Model of KRAB-ZFP binding to DNA and induction of heterochromatin formation. Protein–DNA interaction between ZNFs and DNA are mainly mediated by four amino acids at positions −1, 2, 3, and 6 of the α-helix (colored circles). KAP1 is recruited through the KRAB domain and interacts with the NURD/HDAC repressor complex and histone methyltransferases (HMTs) (e.g. SETDB1), which catalyze the removal of H3K9ac and the addition of H3K9me3, respectively. HP1γ interacts with both KAP1 and H3K9me3. DNA methyltransferases (DNMTs) methylate genomic CpG sites, leading to inheritable silencing

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Mobile DNA

ISSN: 1759-8753