Table 2 Repeat features at the translocation regions studied
Translocation junction regions | Junctions occurring in repeats (%) | Junction to the nearest repeat‡ (bp) | P value for interaction | |
|---|---|---|---|---|
E2A = PBX1 (TCF3-PBX1) | Observed | Expected | ||
TCF3 | 20 (67) | 1 | 42.46 | <0.001†/<0.001* |
PBX1 | 1 (3) | 384.2 | 272.24 | 0.999 |
BCR-ABL | ||||
BCR | 14 (35) | 293.5 | 251.37 | 0.978 |
ABL | 18 (67) | 37.74 | 171.48 | 0.017†/0.449* |
Therapy-related MLLs | ||||
t-MLL | 2 (15.4) | 34.54 | 95.38 | 0.373 |
t-MLLT3 | 3 (23) | 242.85 | 264.64 | 0.949 |
MLLs rearranged | ||||
MLL | 72 (35.3) | 156 | 108.78 | 0.999 |
AFF1 | 46 (21.1) | 208.31 | 144.39 | 0.999 |
MLL | 6 (50) | 50.34 | 82.35 | 0.798 |
MLLT3 | 2 (16.7) | 209.1 | 289.9 | 0.831 |
ETV6-RUNX1 | ||||
ETV6 | 15 (29) | 121.11 | 113.64 | 0.987 |
RUNX1 | 6 (11) | 284.54 | 245.3 | 0.966 |
RUNX1-RUNX1TL | ||||
RUNX1 | 18 (27) | 236.48 | 243.63 | 0.949 |
RUNX1TL | 3 (2) | 494.21 | 264.41 | 0.999 |
MYC-IGH | ||||
MYC | 8 (6) | 399.1 | 116.44 | 0.999 |
IGH | 29 (63) | 668.86 | 298.77 | 0.999 |
BCL6-IGH | ||||
BCL6 | 2 (5) | 151.81 | 174.16 | 0.763 |
IGH | 9 (64) | 124.86 | 190.5 | 0.978 |
SCL-TCRA | ||||
SCL | 1 (6) | 284.43 | 192.11 | 0.998 |
TCRA | 5 (16) | 648.96 | 396.16 | 0.999 |
LMO2-TCRA | ||||
LMO2 | 5 (17) | 160.86 | 208.56 | 0.704 |
TCRA | 3 (10) | 545.1 | 194.47 | 1 |