Figure 8
From: Regulation of DNA transposition by CpG methylation and chromatin structure in human cells
A model of a molecular mechanism of enhanced synaptic complex assembly by condensed DNA packed into heterochromatin. CpG methylation induces heterochromatin condensation whereby the TBSs inside the TIRs will come into close proximity. Hence, the formation of transposase dimers is improved, which subsequently enhances the formation of synaptic complexes. TBS: transposase binding site; TIR: terminal inverted repeat.