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Fig. 3 | Mobile DNA

Fig. 3

From: An intronic LINE-1 regulates IFNAR1 expression in human immune cells

Fig. 3

CRISPR knockout of IFNAR1.L1M2a.enh alters the local chromatin landscape. Wildtype GM12878 cells (light red), as well as a representative IFNAR1.L1M2a.enh knockout clone, L3.E4 (dark red) were characterized by CUT&Tag. The expected bivalent histone modifications and PolII occupancy are present in wildtype GM12878 cells, but both PolII and enhancer associated H3K27ac are lost, and upstream repressive H3K9me3 is increased in knockout clone L3.E4 cells

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ISSN: 1759-8753