Fig. 1
From: SARS-CoV-2 infection induces epigenetic changes in the LTR69 subfamily of endogenous retroviruses
Activation of LTR69 repeats upon SARS-CoV-2 infection. A Volcano plot illustrating differential expression of transposable element (TEs) subfamilies in SARS-CoV-2-infected vs. uninfected Calu-3 cells (GSE147507). Dashed lines represent cutoffs of a log2 fold change of 5 and an adjusted P value of 0.05. B Volcano plot illustrating differential expression of individual TE loci in SARS-CoV-2-infected vs. uninfected Calu-3 cells (GSE147507). Dashed lines represent cutoffs of a log2 fold change of 5 and an adjusted P value of 5e-05. C Enrichment of H3K27Ac peaks in individual TE subfamilies. Dashed lines represent cutoffs of an odds ratio of 5 and a P value of 5e-05. D The average H3K27ac signal profile of LTR69 loci around the transcription start site (TSS) is shown. ChIP-seq data were obtained in SARS-CoV-2 infected (24 h, MOI 0.5) and uninfected A549-ACE2 cells. E Integrative Genomics Viewer (IGV) snapshots of exemplary H3K27ac peaks on individual LTR69 loci (hg38) in A549-ACE2 cells