Fig. 1From: The endonuclease domain of the LINE-1 ORF2 protein can tolerate multiple mutationsMutations in the ORF2 endonuclease domain from full-length L1 loci in the human genome. Bioinformatic analysis using L1Base [36] revealed numerous mutations in the ORF2 endonuclease domains of 134 intact, full-length L1 loci. Positions of mutations relative to the sequence of the L1.3 ORF2 endonuclease domain are indicated by a blue square above the amino acid residueBack to article page