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  1. DNA derived from transposable elements (TEs) constitutes large parts of the genomes of complex eukaryotes, with major impacts not only on genomic research but also on how organisms evolve and function. Althoug...

    Authors: Douglas R. Hoen, Glenn Hickey, Guillaume Bourque, Josep Casacuberta, Richard Cordaux, Cédric Feschotte, Anna-Sophie Fiston-Lavier, Aurélie Hua-Van, Robert Hubley, Aurélie Kapusta, Emmanuelle Lerat, Florian Maumus, David D. Pollock, Hadi Quesneville, Arian Smit, Travis J. Wheeler…
    Citation: Mobile DNA 2015 6:13
    Content type: Commentary Published on:

  2. PHIS transposon superfamily belongs to DNA transposons and includes PIF/Harbinger, ISL2EU, and Spy transposon groups. These three groups have similar DDE domain-containing transposases; however, their coding capa...

    Authors: Min-Jin Han, Chu-Lin Xiong, Hong-Bo Zhang, Meng-Qiang Zhang, Hua-Hao Zhang and Ze Zhang
    Citation: Mobile DNA 2015 6:12
    Content type: Research Published on:

  4. Short interspersed elements (SINEs) have a powerful influence on genome evolution and can be useful markers for phylogenetic inference and population genetic analyses. In this study, we examined survey sequenc...

    Authors: David A Ray, Heidi JT Pagan, Roy N Platt II, Ashley R Kroll, Sarah Schaack and Richard D Stevens
    Citation: Mobile DNA 2015 6:10
    Content type: Research Published on:

  7. Present in the genomes of bacteria and eukaryotic organelles, group II introns are an ancient class of ribozymes and retroelements that are believed to have been the ancestors of nuclear pre-mRNA introns. Desp...

    Authors: Steven Zimmerly and Cameron Semper
    Citation: Mobile DNA 2015 6:7
    Content type: Review Published on:

  8. The Editors of Mobile DNA would like to thank all our reviewers who have contributed to the journal in volume 5 (2014).

    Authors: Nancy L Craig, Thomas H Eikbush, Cédric Feschotte and Henry Levin
    Citation: Mobile DNA 2015 6:6
    Content type: Reviewer acknowledgement Published on:

  10. Human endogenous retroviruses of the HERV-K(HML-2) group have been associated with the development of tumor diseases. Various HERV-K(HML-2) loci encode retrovirus-like proteins, and expression of such proteins...

    Authors: Katja Schmitt, Kristina Heyne, Klaus Roemer, Eckart Meese and Jens Mayer
    Citation: Mobile DNA 2015 6:4
    Content type: Research Published on:

  14. The active human mobile element, long interspersed element 1 (L1) currently populates human genomes in excess of 500,000 copies per haploid genome. Through its mobility via a process called target primed rever...

    Authors: Travis B White, Adam M McCoy, Vincent A Streva, Joshua Fenrich and Prescott L Deininger
    Citation: Mobile DNA 2014 5:30
    Content type: Research Published on:

  15. LINE-1 (L1) retrotransposons are common occupants of mammalian genomes representing about a fifth of the genetic content. Ongoing L1 retrotransposition in the germ line and somatic tissues has contributed to s...

    Authors: Mark Sokolowski, Cecily B DeFreece, Geraldine Servant, Kristine J Kines, Dawn L deHaro and Victoria P Belancio
    Citation: Mobile DNA 2014 5:29
    Content type: Methodology Published on:

  16. Transposable elements (TEs) are major components of genomes. Their mobilization may affect genomic expression and be a threat to genetic stability. This is why they have to be tightly regulated by a dedicated ...

    Authors: Emmanuelle Théron, Cynthia Dennis, Emilie Brasset and Chantal Vaury
    Citation: Mobile DNA 2014 5:28
    Content type: Review Published on:

  17. Hfq functions in post-transcriptional gene regulation in a wide range of bacteria, usually by promoting base pairing of mRNAs with trans-encoded sRNAs. It was previously shown that Hfq down-regulates Tn10 transpo...

    Authors: Joseph A Ross, Ryan S Trussler, Morgan D Black, Crystal R McLellan and David B Haniford
    Citation: Mobile DNA 2014 5:27
    Content type: Research Published on:

  18. The Mobile Genetic Elements and Genome Evolution conference was hosted by Keystone Symposia in Santa Fe, NM USA, 9 March through 14 March 2014. The goal of this conference was to bring together scientists from...

    Authors: Parmit Kumar Singh, Guillaume Bourque, Nancy L Craig, Josh T Dubnau, Cédric Feschotte, Diane A Flasch, Kevin L Gunderson, Harmit Singh Malik, John V Moran, Joseph E Peters, R Keith Slotkin and Henry L Levin
    Citation: Mobile DNA 2014 5:26
    Content type: Meeting Report Published on:

  19. Twin-ribozyme introns represent a complex class of mobile group I introns that harbour a lariat capping (LC) ribozyme and a homing endonuclease gene embedded in a conventional self-splicing group I ribozyme (G...

    Authors: Yunjia Tang, Henrik Nielsen, Benoît Masquida, Paul P Gardner and Steinar D Johansen
    Citation: Mobile DNA 2014 5:25
    Content type: Research Published on:

  20. CACTA elements are DNA transposons and are found in numerous organisms. Despite their low activity, several thousand copies can be identified in many genomes. CACTA elements transpose using a ‘cut-and-paste’ mech...

    Authors: Jan P Buchmann, Ari Löytynoja, Thomas Wicker and Alan H Schulman
    Citation: Mobile DNA 2014 5:24
    Content type: Research Published on:

  22. Transposable elements (TEs) are major structural components of eukaryotic genomes; however, mobilization of TEs generally has negative effects on the host genome. To counteract this threat, host cells have evo...

    Authors: Soichiro Yamanaka, Mikiko C Siomi and Haruhiko Siomi
    Citation: Mobile DNA 2014 5:22
    Content type: Review Published on:

  23. Bari-like transposons belong to the Tc1-mariner superfamily, and they have been identified in several genomes of the Drosophila genus. This transposon’s family has been used as paradigm to investigate the complex...

    Authors: Antonio Palazzo, Roberta Moschetti, Ruggiero Caizzi and René Massimiliano Marsano
    Citation: Mobile DNA 2014 5:21
    Content type: Research Published on:

  24. Processed pseudogenes are copies of messenger RNAs that have been reverse transcribed into DNA and inserted into the genome using the enzymatic activities of active L1 elements. Processed pseudogenes generally...

    Authors: Haig H Kazazian Jr
    Citation: Mobile DNA 2014 5:20
    Content type: Commentary Published on:

  26. During the Mobile Genetic Elements and Genome Evolution Keystone Symposium in March 2014, the Editors of Mobile DNA caught up with a panel of conference speakers to select key advances in the field, and hear thei...

    Authors: Marlene Belfort, Luciano Marraffini, Todd Macfarlan, Jef Boeke, Keith Slotkin, Harmit Malik and Lynne Maquat
    Citation: Mobile DNA 2014 5:16
    Content type: Opinion Published on:

  27. The Drosophila INterspersed Elements-1 (DINE-1/INE1) transposable elements (TEs) are the most abundant component of the Drosophila melanogaster genome and have been associated with functional gene duplications. D...

    Authors: Jainy Thomas, Komal Vadnagara and Ellen J Pritham
    Citation: Mobile DNA 2014 5:18
    Content type: Research Published on:

  28. The Tc1/mariner superfamily of transposable elements (TEs) is widespread in animal genomes. Mariner-like elements, which bear a DDD triad catalytic motif, have been identified in a wide range of flowering plant s...

    Authors: Yuan Liu and Guojun Yang
    Citation: Mobile DNA 2014 5:17
    Content type: Research Published on:

  30. Mammalian-wide interspersed repeats (MIRs) are the most ancient family of transposable elements (TEs) in the human genome. The deep conservation of MIRs initially suggested the possibility that they had been e...

    Authors: Daudi Jjingo, Andrew B Conley, Jianrong Wang, Leonardo Mariño-Ramírez, Victoria V Lunyak and I King Jordan
    Citation: Mobile DNA 2014 5:14
    Content type: Research Published on:

  32. Trichomonas vaginalis is the most prevalent non-viral sexually transmitted parasite. Although the protist is presumed to reproduce asexually, 60% of its haploid genome contains transposable elements (TEs), known ...

    Authors: Martina Bradic, Sally D Warring, Vivien Low and Jane M Carlton
    Citation: Mobile DNA 2014 5:12
    Content type: Research Published on:

  33. LINE-1s (L1s), the only currently active autonomous mobile DNA in humans, occupy at least 17% of human DNA. Throughout evolution, the L1 has also been responsible for genomic insertion of thousands of processe...

    Authors: John L Goodier
    Citation: Mobile DNA 2014 5:11
    Content type: Commentary Published on:

  34. Tos17 was the first LTR retrotransposon (Copia) described as active in cultivated rice, and is present in two copies in the genome of the sequenced Nipponbare variety. Only the chromosome 7 copy is active and abl...

    Authors: Francois Sabot
    Citation: Mobile DNA 2014 5:10
    Content type: Research Published on:

  36. Group I introns are intervening sequences that have invaded tRNA, rRNA and protein coding genes in bacteria and their phages. The ability of group I introns to self-splice from their host transcripts, by actin...

    Authors: Georg Hausner, Mohamed Hafez and David R Edgell
    Citation: Mobile DNA 2014 5:8
    Content type: Review Published on:

  38. The Editors of Mobile DNA would like to thank all our reviewers who have contributed to the journal in volume 4 (2013).

    Authors: Nancy L Craig, Thomas H Eickbush, Cédric Feschotte and Henry L Levin
    Citation: Mobile DNA 2014 5:3
    Content type: Reviewer Acknowledgement Published on:

  39. Hybrid dysgenic syndromes in Drosophila have been critical for characterizing host mechanisms of transposable element (TE) regulation. This is because a common feature of hybrid dysgenesis is germline TE mobiliza...

    Authors: Justin P Blumenstiel
    Citation: Mobile DNA 2014 5:6
    Content type: Research Published on:

  41. Horizontal transfer of transposable elements (HTT) is increasingly appreciated as an important source of genome and species evolution in eukaryotes. However, our understanding of HTT dynamics is still poor in ...

    Authors: Mathilde Dupeyron, Sébastien Leclercq, Nicolas Cerveau, Didier Bouchon and Clément Gilbert
    Citation: Mobile DNA 2014 5:4
    Content type: Research Published on:

  42. Mobile group II introns are bacterial retrotransposons that combine the activities of an autocatalytic intron RNA (a ribozyme) and an intron-encoded reverse transcriptase to insert site-specifically into DNA. ...

    Authors: Peter J Enyeart, Georg Mohr, Andrew D Ellington and Alan M Lambowitz
    Citation: Mobile DNA 2014 5:2
    Content type: Review Published on:

  43. Transposable elements (TEs) play a major role in genome evolution. Their capacity to move and/or multiply in the genome of their host may have profound impacts on phenotypes and dramatic consequences on genome...

    Authors: Roland Vergilino, Shannon HC Eagle, Teresa J Crease and France Dufresne
    Citation: Mobile DNA 2014 5:1
    Content type: Research Published on:

  44. Accurate and complete identification of mobile elements is a challenging task in the current era of sequencing, given their large numbers and frequent truncations. Group II intron retroelements, which consist ...

    Authors: Michael Abebe, Manuel A Candales, Adrian Duong, Keyar S Hood, Tony Li, Ryan A E Neufeld, Abat Shakenov, Runda Sun, Li Wu, Ashley M Jarding, Cameron Semper and Steven Zimmerly
    Citation: Mobile DNA 2013 4:28
    Content type: Software Published on:

  46. Research into great ape genomes has revealed widely divergent activity levels over time for Alu elements. However, the diversity of this mobile element family in the genome of the western lowland gorilla has prev...

    Authors: Adam T McLain, Glenn W Carman, Mitchell L Fullerton, Thomas O Beckstrom, William Gensler, Thomas J Meyer, Christopher Faulk and Mark A Batzer
    Citation: Mobile DNA 2013 4:26
    Content type: Research Published on:

  49. piggyBac domain (PGBD) transposons are found in organisms ranging from fungi to humans. Three domesticated piggyBac elements have been described. In the ciliates Paramecium tetraurelia and Tetrahymena thermophila

    Authors: Thomas Pavelitz, Lucas T Gray, Stephanie L Padilla, Arnold D Bailey and Alan M Weiner
    Citation: Mobile DNA 2013 4:23
    Content type: Research Published on:

  50. Hematolymphoid neoplasms frequently harbor recurrent genetic abnormalities. Some of the most well recognized lesions are chromosomal translocations, and many of these are known to play pivotal roles in pathoge...

    Authors: Nemanja Rodić, John G Zampella, Toby C Cornish, Sarah J Wheelan and Kathleen H Burns
    Citation: Mobile DNA 2013 4:22
    Content type: Research Published on:
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ISSN: 1759-8753