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  1. Gliomas are the most common primary brain tumors in adults. We sought to understand the roles of endogenous transposable elements in these malignancies by identifying evidence of somatic retrotransposition in ...

    Authors: Pragathi Achanta, Jared P. Steranka, Zuojian Tang, Nemanja Rodić, Reema Sharma, Wan Rou Yang, Sisi Ma, Mark Grivainis, Cheng Ran Lisa Huang, Anna M. Schneider, Gary L. Gallia, Gregory J. Riggins, Alfredo Quinones-Hinojosa, David Fenyö, Jef D. Boeke and Kathleen H. Burns
    Citation: Mobile DNA 2016 7:22
    Content type: Research Published on:

  2. LINE-1 (L1) retrotransposons are a notable endogenous source of mutagenesis in mammals. Notably, cancer cells can support unusual L1 retrotransposition and L1-associated sequence rearrangement mechanisms follo...

    Authors: Patricia E. Carreira, Adam D. Ewing, Guibo Li, Stephanie N. Schauer, Kyle R. Upton, Allister C. Fagg, Santiago Morell, Michaela Kindlova, Patricia Gerdes, Sandra R. Richardson, Bo Li, Daniel J. Gerhardt, Jun Wang, Paul M. Brennan and Geoffrey J. Faulkner
    Citation: Mobile DNA 2016 7:21
    Content type: Research Published on:

  3. The National Cancer Institute-60 (NCI-60) cell lines are among the most widely used models of human cancer. They provide a platform to integrate DNA sequence information, epigenetic data, RNA and protein expre...

    Authors: John G. Zampella, Nemanja Rodić, Wan Rou Yang, Cheng Ran Lisa Huang, Jane Welch, Veena P. Gnanakkan, Toby C. Cornish, Jef D. Boeke and Kathleen H. Burns
    Citation: Mobile DNA 2016 7:20
    Content type: Research Published on:

  4. The third international conference on Transposable Elements (ICTE) was held 16–19 April 2016 in Saint Malo, France. Organized by the French Transposition Community (Research group of the CNRS: “Mobile genetic ...

    Authors: Pascale Lesage, Mireille Bétermier, Antoine Bridier-Nahmias, Michael Chandler, Séverine Chambeyron, Gael Cristofari, Nicolas Gilbert, Hadi Quesneville, Chantal Vaury and Jean-Nicolas Volff
    Citation: Mobile DNA 2016 7:19
    Content type: Meeting report Published on:

  5. Retrotransposed genes are different to other types of genes as they originate from a processed mRNA and are then inserted back into the genome. For a long time, the contribution of this mechanism to the origin...

    Authors: Pengjun Xu, Roberto Feuda, Bin Lu, Haijun Xiao, Robert I. Graham and Kongming Wu
    Citation: Mobile DNA 2016 7:18
    Content type: Short report Published on:

  7. Retrotransposons have generated about 40 % of the human genome. This review examines the strategies the cell has evolved to coexist with these genomic “parasites”, focussing on the non-long terminal repeat ret...

    Authors: John L. Goodier
    Citation: Mobile DNA 2016 7:16
    Content type: Review Published on:

  9. The genomic data available nowadays has enabled the study of repetitive sequences and their relationship to viruses. Among them, long terminal repeat retrotransposons (LTR-RTs) are the largest component of mos...

    Authors: Edgar Andres Ochoa Cruz, Guilherme Marcello Queiroga Cruz, Andréia Prata Vieira and Marie-Anne Van Sluys
    Citation: Mobile DNA 2016 7:14
    Content type: Research Published on:

  13. Retrotransposons are mobile elements that have a high impact on shaping the mammalian genomes. Since the availability of whole genomes, genomic analyses have provided novel insights into retrotransposon biolog...

    Authors: Georgios Markopoulos, Dimitrios Noutsopoulos, Stefania Mantziou, Demetrios Gerogiannis, Soteroula Thrasyvoulou, Georgios Vartholomatos, Evangelos Kolettas and Theodore Tzavaras
    Citation: Mobile DNA 2016 7:10
    Content type: Research Published on:

  14. Over evolutionary time, the dynamic nature of a genome is driven, in part, by the activity of transposable elements (TE) such as retrotransposons. On a shorter time scale it has been established that new TE in...

    Authors: Dustin C. Hancks and Haig H. Kazazian Jr.
    Citation: Mobile DNA 2016 7:9
    Content type: Review Published on:

  15. Approximately 17 % of the human genome is comprised of the Long INterspersed Element-1 (LINE-1 or L1) retrotransposon, the only currently active autonomous family of retroelements. Though L1 elements have helped ...

    Authors: Kristine J. Kines, Mark Sokolowski, Dawn L. deHaro, Claiborne M. Christian, Melody Baddoo, Madison E. Smither and Victoria P. Belancio
    Citation: Mobile DNA 2016 7:8
    Content type: Research Published on:

  17. The revolutionary concept of “jumping genes” was conceived by McClintock in the late 1940s while studying the Activator/Dissociation (Ac/Ds) system in maize. Transposable elements (TEs) represent the most abundan...

    Authors: Jun Ni, Kirk J. Wangensteen, David Nelsen, Darius Balciunas, Kimberly J. Skuster, Mark D. Urban and Stephen C. Ekker
    Citation: Mobile DNA 2016 7:6
    Content type: Research Published on:

  20. A critical topic of insertional mutagenesis experiments performed on model organisms is mapping the hits of artificial transposons (ATs) at nucleotide level accuracy. Mapping errors may occur when sequencing a...

    Authors: Alexandru Al. Ecovoiu, Iulian Constantin Ghionoiu, Andrei Mihai Ciuca and Attila Cristian Ratiu
    Citation: Mobile DNA 2016 7:3
    Content type: Software Published on:

  22. Long terminal repeat (LTR)-retrotransposons constitute 42.4 % of the genome of the ‘Suli’ pear (Pyrus pyrifolia white pear group), implying that retrotransposons have played important roles in Pyrus evolution. Th...

    Authors: Shuang Jiang, Danying Cai, Yongwang Sun and Yuanwen Teng
    Citation: Mobile DNA 2016 7:1
    Content type: Research Published on:

  25. A large number of Saccharomyces cerevisiae cellular factors modulate the movement of the retrovirus-like transposon Ty1. Surprisingly, a significant number of chromosomal genes required for Ty1 transposition enco...

    Authors: Susmitha Suresh, Hyo Won Ahn, Kartikeya Joshi, Arun Dakshinamurthy, Arun Kannanganat, David J. Garfinkel and Philip J. Farabaugh
    Citation: Mobile DNA 2015 6:22
    Content type: Research Published on:

    The Erratum to this article has been published in Mobile DNA 2016 7:5

  26. The human genome contains several active families of transposable elements (TE): Alu, L1 and SVA. Germline transposition of these elements can lead to polymorphic TE (polyTE) loci that differ between individua...

    Authors: Lavanya Rishishwar, Carlos E. Tellez Villa and I. King Jordan
    Citation: Mobile DNA 2015 6:21
    Content type: Research Published on:

  27. The First International Scientific Conference on Human Endogenous Retroviruses (HERVs) and Disease, Lyon-France, May 26-27th 2015, brought together scientific and medical specialists from around the world investi...

    Authors: Avindra Nath, Patrick Küry, Guilherme Sciascia do Olival, Antonina Dolei, Håkan Karlsson, Laurent Groc, Marion Schneider, John Kriesel, Jean-Louis Touraine, François Mallet, Patrice N. Marche, Frederick Arnaud, Cédric Feschotte and Hervé Perron
    Citation: Mobile DNA 2015 6:20
    Content type: Meeting Report Published on:

  28. Transposable elements (TEs) are common constituents of centromeres. However, it is not known what causes this relationship. Schizosaccharomyces japonicus contains 10 families of Long Terminal Repeat (LTR)-retrotr...

    Authors: Yabin Guo, Parmit Kumar Singh and Henry L. Levin
    Citation: Mobile DNA 2015 6:19
    Content type: Research Published on:

  29. Repetitive regions of DNA and transposable elements have been found to constitute large percentages of eukaryotic and prokaryotic genomes. Such elements are known to be involved in transcriptional regulation, ...

    Authors: Brian A. Klein, Tsute Chen, Jodie C. Scott, Andrea L. Koenigsberg, Margaret J. Duncan and Linden T. Hu
    Citation: Mobile DNA 2015 6:18
    Content type: Research Published on:

  30. Tandem C2H2-type zinc finger proteins (ZFPs) constitute the largest transcription factor family in animals. Tandem-ZFPs bind DNA in a sequence-specific manner through arrays of multiple zinc finger domains tha...

    Authors: Gernot Wolf, David Greenberg and Todd S. Macfarlan
    Citation: Mobile DNA 2015 6:17
    Content type: Review Published on:

  31. The discovery of many fragments of viral genomes integrated in the genome of their eukaryotic host (endogenous viral elements; EVEs) has recently opened new avenues to further our understanding of viral evolut...

    Authors: Gabriel Metegnier, Thomas Becking, Mohamed Amine Chebbi, Isabelle Giraud, Bouziane Moumen, Sarah Schaack, Richard Cordaux and Clément Gilbert
    Citation: Mobile DNA 2015 6:16
    Content type: Research Published on:

  32. A key difference between the Tourist and Stowaway families of miniature inverted repeat transposable elements (MITEs) is the manner in which their excision alters the genome. Upon excision, Stowaway-like MITEs an...

    Authors: David M. Gilbert, M. Catherine Bridges, Ashley E. Strother, Courtney E. Burckhalter, James M. Burnette III and C. Nathan Hancock
    Citation: Mobile DNA 2015 6:15
    Content type: Research Published on:

  33. In the compact and haploid genome of Dictyostelium discoideum control of transposon activity is of particular importance to maintain viability. The non-long terminal repeat retrotransposon TRE5-A amplifies contin...

    Authors: Anika Schmith, Thomas Spaller, Friedemann Gaube, Åsa Fransson, Benjamin Boesler, Sandeep Ojha, Wolfgang Nellen, Christian Hammann, Fredrik Söderbom and Thomas Winckler
    Citation: Mobile DNA 2015 6:14
    Content type: Research Published on:

  34. DNA derived from transposable elements (TEs) constitutes large parts of the genomes of complex eukaryotes, with major impacts not only on genomic research but also on how organisms evolve and function. Althoug...

    Authors: Douglas R. Hoen, Glenn Hickey, Guillaume Bourque, Josep Casacuberta, Richard Cordaux, Cédric Feschotte, Anna-Sophie Fiston-Lavier, Aurélie Hua-Van, Robert Hubley, Aurélie Kapusta, Emmanuelle Lerat, Florian Maumus, David D. Pollock, Hadi Quesneville, Arian Smit, Travis J. Wheeler…
    Citation: Mobile DNA 2015 6:13
    Content type: Commentary Published on:

  35. PHIS transposon superfamily belongs to DNA transposons and includes PIF/Harbinger, ISL2EU, and Spy transposon groups. These three groups have similar DDE domain-containing transposases; however, their coding capa...

    Authors: Min-Jin Han, Chu-Lin Xiong, Hong-Bo Zhang, Meng-Qiang Zhang, Hua-Hao Zhang and Ze Zhang
    Citation: Mobile DNA 2015 6:12
    Content type: Research Published on:

  37. Short interspersed elements (SINEs) have a powerful influence on genome evolution and can be useful markers for phylogenetic inference and population genetic analyses. In this study, we examined survey sequenc...

    Authors: David A Ray, Heidi JT Pagan, Roy N Platt II, Ashley R Kroll, Sarah Schaack and Richard D Stevens
    Citation: Mobile DNA 2015 6:10
    Content type: Research Published on:

  40. Present in the genomes of bacteria and eukaryotic organelles, group II introns are an ancient class of ribozymes and retroelements that are believed to have been the ancestors of nuclear pre-mRNA introns. Desp...

    Authors: Steven Zimmerly and Cameron Semper
    Citation: Mobile DNA 2015 6:7
    Content type: Review Published on:

  41. The Editors of Mobile DNA would like to thank all our reviewers who have contributed to the journal in volume 5 (2014).

    Authors: Nancy L Craig, Thomas H Eikbush, Cédric Feschotte and Henry Levin
    Citation: Mobile DNA 2015 6:6
    Content type: Reviewer acknowledgement Published on:

  43. Human endogenous retroviruses of the HERV-K(HML-2) group have been associated with the development of tumor diseases. Various HERV-K(HML-2) loci encode retrovirus-like proteins, and expression of such proteins...

    Authors: Katja Schmitt, Kristina Heyne, Klaus Roemer, Eckart Meese and Jens Mayer
    Citation: Mobile DNA 2015 6:4
    Content type: Research Published on:

  47. The active human mobile element, long interspersed element 1 (L1) currently populates human genomes in excess of 500,000 copies per haploid genome. Through its mobility via a process called target primed rever...

    Authors: Travis B White, Adam M McCoy, Vincent A Streva, Joshua Fenrich and Prescott L Deininger
    Citation: Mobile DNA 2014 5:30
    Content type: Research Published on:

  48. LINE-1 (L1) retrotransposons are common occupants of mammalian genomes representing about a fifth of the genetic content. Ongoing L1 retrotransposition in the germ line and somatic tissues has contributed to s...

    Authors: Mark Sokolowski, Cecily B DeFreece, Geraldine Servant, Kristine J Kines, Dawn L deHaro and Victoria P Belancio
    Citation: Mobile DNA 2014 5:29
    Content type: Methodology Published on:

  49. Transposable elements (TEs) are major components of genomes. Their mobilization may affect genomic expression and be a threat to genetic stability. This is why they have to be tightly regulated by a dedicated ...

    Authors: Emmanuelle Théron, Cynthia Dennis, Emilie Brasset and Chantal Vaury
    Citation: Mobile DNA 2014 5:28
    Content type: Review Published on:

  50. Hfq functions in post-transcriptional gene regulation in a wide range of bacteria, usually by promoting base pairing of mRNAs with trans-encoded sRNAs. It was previously shown that Hfq down-regulates Tn10 transpo...

    Authors: Joseph A Ross, Ryan S Trussler, Morgan D Black, Crystal R McLellan and David B Haniford
    Citation: Mobile DNA 2014 5:27
    Content type: Research Published on:
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ISSN: 1759-8753