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  1. The Mobile Genetic Elements and Genome Evolution conference was hosted by Keystone Symposia in Santa Fe, NM USA, 9 March through 14 March 2014. The goal of this conference was to bring together scientists from...

    Authors: Parmit Kumar Singh, Guillaume Bourque, Nancy L Craig, Josh T Dubnau, Cédric Feschotte, Diane A Flasch, Kevin L Gunderson, Harmit Singh Malik, John V Moran, Joseph E Peters, R Keith Slotkin and Henry L Levin
    Citation: Mobile DNA 2014 5:26
  2. Twin-ribozyme introns represent a complex class of mobile group I introns that harbour a lariat capping (LC) ribozyme and a homing endonuclease gene embedded in a conventional self-splicing group I ribozyme (G...

    Authors: Yunjia Tang, Henrik Nielsen, Benoît Masquida, Paul P Gardner and Steinar D Johansen
    Citation: Mobile DNA 2014 5:25
  3. CACTA elements are DNA transposons and are found in numerous organisms. Despite their low activity, several thousand copies can be identified in many genomes. CACTA elements transpose using a ‘cut-and-paste’ mech...

    Authors: Jan P Buchmann, Ari Löytynoja, Thomas Wicker and Alan H Schulman
    Citation: Mobile DNA 2014 5:24
  4. Transposable elements (TEs) are major structural components of eukaryotic genomes; however, mobilization of TEs generally has negative effects on the host genome. To counteract this threat, host cells have evo...

    Authors: Soichiro Yamanaka, Mikiko C Siomi and Haruhiko Siomi
    Citation: Mobile DNA 2014 5:22
  5. Bari-like transposons belong to the Tc1-mariner superfamily, and they have been identified in several genomes of the Drosophila genus. This transposon’s family has been used as paradigm to investigate the complex...

    Authors: Antonio Palazzo, Roberta Moschetti, Ruggiero Caizzi and René Massimiliano Marsano
    Citation: Mobile DNA 2014 5:21
  6. Processed pseudogenes are copies of messenger RNAs that have been reverse transcribed into DNA and inserted into the genome using the enzymatic activities of active L1 elements. Processed pseudogenes generally...

    Authors: Haig H Kazazian Jr
    Citation: Mobile DNA 2014 5:20
  7. During the Mobile Genetic Elements and Genome Evolution Keystone Symposium in March 2014, the Editors of Mobile DNA caught up with a panel of conference speakers to select key advances in the field, and hear thei...

    Authors: Marlene Belfort, Luciano Marraffini, Todd Macfarlan, Jef Boeke, Keith Slotkin, Harmit Malik and Lynne Maquat
    Citation: Mobile DNA 2014 5:16
  8. The Drosophila INterspersed Elements-1 (DINE-1/INE1) transposable elements (TEs) are the most abundant component of the Drosophila melanogaster genome and have been associated with functional gene duplications. D...

    Authors: Jainy Thomas, Komal Vadnagara and Ellen J Pritham
    Citation: Mobile DNA 2014 5:18
  9. The Tc1/mariner superfamily of transposable elements (TEs) is widespread in animal genomes. Mariner-like elements, which bear a DDD triad catalytic motif, have been identified in a wide range of flowering plant s...

    Authors: Yuan Liu and Guojun Yang
    Citation: Mobile DNA 2014 5:17
  10. Mammalian-wide interspersed repeats (MIRs) are the most ancient family of transposable elements (TEs) in the human genome. The deep conservation of MIRs initially suggested the possibility that they had been e...

    Authors: Daudi Jjingo, Andrew B Conley, Jianrong Wang, Leonardo Mariño-Ramírez, Victoria V Lunyak and I King Jordan
    Citation: Mobile DNA 2014 5:14
  11. Trichomonas vaginalis is the most prevalent non-viral sexually transmitted parasite. Although the protist is presumed to reproduce asexually, 60% of its haploid genome contains transposable elements (TEs), known ...

    Authors: Martina Bradic, Sally D Warring, Vivien Low and Jane M Carlton
    Citation: Mobile DNA 2014 5:12
  12. LINE-1s (L1s), the only currently active autonomous mobile DNA in humans, occupy at least 17% of human DNA. Throughout evolution, the L1 has also been responsible for genomic insertion of thousands of processe...

    Authors: John L Goodier
    Citation: Mobile DNA 2014 5:11
  13. Tos17 was the first LTR retrotransposon (Copia) described as active in cultivated rice, and is present in two copies in the genome of the sequenced Nipponbare variety. Only the chromosome 7 copy is active and abl...

    Authors: Francois Sabot
    Citation: Mobile DNA 2014 5:10
  14. Group I introns are intervening sequences that have invaded tRNA, rRNA and protein coding genes in bacteria and their phages. The ability of group I introns to self-splice from their host transcripts, by actin...

    Authors: Georg Hausner, Mohamed Hafez and David R Edgell
    Citation: Mobile DNA 2014 5:8
  15. The Editors of Mobile DNA would like to thank all our reviewers who have contributed to the journal in volume 4 (2013).

    Authors: Nancy L Craig, Thomas H Eickbush, Cédric Feschotte and Henry L Levin
    Citation: Mobile DNA 2014 5:3
  16. Hybrid dysgenic syndromes in Drosophila have been critical for characterizing host mechanisms of transposable element (TE) regulation. This is because a common feature of hybrid dysgenesis is germline TE mobiliza...

    Authors: Justin P Blumenstiel
    Citation: Mobile DNA 2014 5:6
  17. Horizontal transfer of transposable elements (HTT) is increasingly appreciated as an important source of genome and species evolution in eukaryotes. However, our understanding of HTT dynamics is still poor in ...

    Authors: Mathilde Dupeyron, Sébastien Leclercq, Nicolas Cerveau, Didier Bouchon and Clément Gilbert
    Citation: Mobile DNA 2014 5:4
  18. Mobile group II introns are bacterial retrotransposons that combine the activities of an autocatalytic intron RNA (a ribozyme) and an intron-encoded reverse transcriptase to insert site-specifically into DNA. ...

    Authors: Peter J Enyeart, Georg Mohr, Andrew D Ellington and Alan M Lambowitz
    Citation: Mobile DNA 2014 5:2
  19. Transposable elements (TEs) play a major role in genome evolution. Their capacity to move and/or multiply in the genome of their host may have profound impacts on phenotypes and dramatic consequences on genome...

    Authors: Roland Vergilino, Shannon HC Eagle, Teresa J Crease and France Dufresne
    Citation: Mobile DNA 2014 5:1
  20. Accurate and complete identification of mobile elements is a challenging task in the current era of sequencing, given their large numbers and frequent truncations. Group II intron retroelements, which consist ...

    Authors: Michael Abebe, Manuel A Candales, Adrian Duong, Keyar S Hood, Tony Li, Ryan A E Neufeld, Abat Shakenov, Runda Sun, Li Wu, Ashley M Jarding, Cameron Semper and Steven Zimmerly
    Citation: Mobile DNA 2013 4:28
  21. Research into great ape genomes has revealed widely divergent activity levels over time for Alu elements. However, the diversity of this mobile element family in the genome of the western lowland gorilla has prev...

    Authors: Adam T McLain, Glenn W Carman, Mitchell L Fullerton, Thomas O Beckstrom, William Gensler, Thomas J Meyer, Christopher Faulk and Mark A Batzer
    Citation: Mobile DNA 2013 4:26
  22. piggyBac domain (PGBD) transposons are found in organisms ranging from fungi to humans. Three domesticated piggyBac elements have been described. In the ciliates Paramecium tetraurelia and Tetrahymena thermophila

    Authors: Thomas Pavelitz, Lucas T Gray, Stephanie L Padilla, Arnold D Bailey and Alan M Weiner
    Citation: Mobile DNA 2013 4:23
  23. Hematolymphoid neoplasms frequently harbor recurrent genetic abnormalities. Some of the most well recognized lesions are chromosomal translocations, and many of these are known to play pivotal roles in pathoge...

    Authors: Nemanja Rodić, John G Zampella, Toby C Cornish, Sarah J Wheelan and Kathleen H Burns
    Citation: Mobile DNA 2013 4:22
  24. Transposable elements (TEs) have the potential to impact genome structure, function and evolution in profound ways. In order to understand the contribution of transposable elements (TEs) to Heliconius melpomene, ...

    Authors: Christine A Lavoie, Roy N Platt II, Peter A Novick, Brian A Counterman and David A Ray
    Citation: Mobile DNA 2013 4:21
  25. Only a few transposable elements are known to exhibit site-specific insertion patterns, including the well-studied R-element retrotransposons that insert into specific sites within the multigene rDNA. The only...

    Authors: Tyler A Elliott, Deborah E Stage, Teresa J Crease and Thomas H Eickbush
    Citation: Mobile DNA 2013 4:20
  26. Penelope-like elements (PLEs) are an enigmatic group of retroelements sharing a common ancestor with telomerase reverse transcriptases. In our previous studies, we identified endonuclease-deficient PLEs that are ...

    Authors: Irina R Arkhipova, Irina A Yushenova and Fernando Rodriguez
    Citation: Mobile DNA 2013 4:19
  27. Telomere maintenance in Drosophila relies on the targeted transposition of three very special non-LTR retrotransposons, HeT-A, TART, and TAHRE (HTT). The sequences of the retrotransposon array build up the telome...

    Authors: Rute Silva-Sousa, Míriam Díaz Varela and Elena Casacuberta
    Citation: Mobile DNA 2013 4:18
  28. Group I introns are a distinct class of RNA self-splicing introns with an ancient origin. All known group I introns present in eukaryote nuclei interrupt functional ribosomal RNA genes located in ribosomal DNA...

    Authors: Annica Hedberg and Steinar D Johansen
    Citation: Mobile DNA 2013 4:17
  29. The non-long terminal repeat (non-LTR) retrotransposons, long interspersed element-1 (LINE-1) and Alu are currently active retroelements in humans. We, and others, have observed that different populations of H...

    Authors: Vincent A Streva, Zachary J Faber and Prescott L Deininger
    Citation: Mobile DNA 2013 4:16
  30. Long interspersed element type one (L1) actively modifies the human genome by inserting new copies of itself. This process, termed retrotransposition, requires the formation of an L1 ribonucleoprotein (RNP) co...

    Authors: Yi Xie, Lajos Mates, Zoltán Ivics, Zsuzsanna Izsvák, Sandra L Martin and Wenfeng An
    Citation: Mobile DNA 2013 4:10
  31. Chromoviruses are one of the three genera of Ty3-gypsy long terminal repeat (LTR) retrotransposons, and are present in high copy numbers in plant genomes. They are widely distributed within the plant kingdom, wit...

    Authors: Beatrice Weber, Tony Heitkam, Daniela Holtgräwe, Bernd Weisshaar, André E Minoche, Juliane C Dohm, Heinz Himmelbauer and Thomas Schmidt
    Citation: Mobile DNA 2013 4:8
  32. The editors of Mobile DNA would like to thank all our reviewers who have contributed to the journal in volume 3 (2012).

    Authors: Nancy L Craig, Thomas H Eikbush and Daniel F Voytas
    Citation: Mobile DNA 2013 4:4
  33. Transposable elements play a major role in genome evolution. Their capacity to move and/or multiply in the genome of their host may have profound impacts on phenotypes, and may have dramatic consequences on ge...

    Authors: Roland Vergilino, Tyler A Elliott, Philippe Desjardins-Proulx, Teresa J Crease and France Dufresne
    Citation: Mobile DNA 2013 4:7
  34. Galileo is a transposable element responsible for the generation of three chromosomal inversions in natural populations of Drosophila buzzatii. Although the most characteristic feature of Galileo is the long inte...

    Authors: Mar Marzo, Xabier Bello, Marta Puig, Xulio Maside and Alfredo Ruiz
    Citation: Mobile DNA 2013 4:6

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