Fig. 4

Expression of genes involved in post-translational regulation of ORF1p and ORF2p or nucleic acid sensing and signaling to type I interferon induction in neutrophils from SLE patients and healthy volunteers. A Schematic representation of the molecular machinery upstream and downstream of the L1 proteins and normalized read counts of the indicated genes in HC and SLE patients segregated by disease activity. B Normalized read counts of the same genes in HC and SLE patients segregated in interferon gene signature (ISGs). Bars indicate mean ± standard deviation. * denotes p values < 0.05, ** p < 0.01, *** p < 0.005, and *** p < 0.001. ns, not significant