Fig. 3
LTR30 expression strongly correlates with innate immune genes and RIG-I sensor expression. PCA plot of SCLC samples dataset based on innate sensors gene and A) LTR30 or B) MER74C expression. The PCA loadings describing the contribution to the components of each gene and TE are represented as labelled arrows. Points correspond to SCLC tumour samples (n = 104). Colour: Response to type I Interferon ssGSEA scores, as in legend. C Main: Scatter plot of correlation between log2 normalized counts of LTR30 expression (x-axis) and log2 normalized counts of RIG-I expression (y-axis). Points correspond to SCLC tumour samples (n = 104). Colour: Response to type I Interferon ssGSEA scores, as in legend. Spearman’s rho (R) and p-values of correlation (p) are reported. Down: Violin plot of LTR30 expression in samples with low levels of Response to type I Interferon (blue, NES < − 0.2) or with high levels of Response to type I Interferon (red, NES > 0.2). Left: Violin plot of RIG-I expression in samples with low levels of Response to type I Interferon (blue, NES < − 0.2) or high levels of Response to type I Interferon (red, NES > 0.2). Wilcoxon test p-values are reported: * 0.01-0.05, ** 0.0001-0.01, *** 0,00001-0.0001, **** < 0,000001. D Same as in C) but for MER74C