Fig. 5

Epigenomic profiling of untreated and IFNa-stimulated embryonic fibroblast primary cells. A Genome browser view of the IRF9 and PSME2 loci. RNA-seq and CUT&RUN tracks are normalized per million reads. Signal track maxima are indicated on the right of each track. IFNa-inducible (p-value < 0.10, log2FC > 0) STAT1 peaks are highlighted orange. B MA plot of IFNa-inducible (unadjusted p-value < 0.10, log2FC > 0, blue) and IFNa-repressed (unadjusted p-value < 0.10, log2FC < 0, orange) H3K27ac regions from H3K27ac CUT&RUN. Regions with an unadjusted p-value > 0.10 are shown in grey. Log2 fold change values were shrunken using the apeglm function v1.8.0 [41]. C Heatmaps showing normalized CUT&RUN signal (signal per million reads) over IFNa-inducible (unadjusted p-val < 0.10), H3K27ac-marked MIR families. D Heatmaps showing normalized CUT&RUN signal (signal per million reads) over H3K27ac-marked LTR13C_ML families