Fig. 4

TE exonization events in Myotis ISGs. Custom UCSC genome browser screenshot of the NLRC5 locus, where one exon (light blue highlight) represents a potential alternative transcription start site (TSS) deriving from a Myotis-specific LTR39B2_ML retrotransposons. RNAseq coverage at the promoter region suggests upregulation of the transcript at 4 h post IFNa treatment, consistent with its role in immune responses, and lower expression in 24 h post treatment samples compared to unstimulated cells. We also identified 2 potential TE-derived regulatory elements (orange highlight) in intronic or upstream regions of the NLRC5 locus that show increase in H3K27ac and STAT1 CUT&RUN signal at 4 h post IFNa treatment