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Fig. 3 | Mobile DNA

Fig. 3

From: Transcriptional dynamics of transposable elements in the type I IFN response in Myotis lucifugus cells

Fig. 3

Gene expression profiles and enrichment analyses. A Heatmap shows the 140 genes with highest expression variance across samples in vsd transformed data (clustering method: “euclidean”). Embryonic fibroblast cells presented four different profiles of gene induction dynamics through time: i) genes with rapid induction and decline at 24 h (Group I); ii) genes with mild induction at 4 h and low decline at 24 h or with stable induction (Groups II and III); and iii) genes with rapid induction at 4 h and rapid decline (Group IV). B Bar graphs show the results of functional overrepresentation analysis (ORA) on differentially expressed genes at 4 h and 24 h post IFNa treatment. Although most terms are shared between the two time points, we found the DDX58/IFIH1 pathway to be active at 4 h post IFNa stimulation, whereas it is subject to negative regulation at 24 h. Similarly, the response to cytokine stimuli is present at 4 h post treatment, but not at 24 h

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