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Fig. 2 | Mobile DNA

Fig. 2

From: SETMAR, a case of primate co-opted genes: towards new perspectives

Fig. 2

Overview of SETMAR activities, involved in replication fork restart after repair, NHEJ DNA repair, chromosomes decatenation and various epigenetics mechanisms. Usual cancer treatments are shown in red (IR: radiation, VP-16 and HU: chemicals). Cellular pathways activated or supported by SETMAR are represented in green. Identified post-translational modifications (PTM) and SETMAR partners are indicated. The picture only concerns FL-SETMAR activities because S-SETMAR activities are not well documented. So far, we know that S-SETMAR disturbs the NHEJ activity of FL-SETMAR, and does not display methyl-transferase activity

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