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Fig. 1 | Mobile DNA

Fig. 1

From: Eco-evolutionary significance of domesticated retroelements in microbial genomes

Fig. 1

Overview of the molecular mechanisms of DGRs and retrons. DGRs and retrons are highlighted among other modern retroelements, with group-II introns shown as the ancestral progenitor. A prototypical DGR is depicted with the stages of adenine mutagenesis and retrohoming that involves template (TR) ncRNA (non-coding RNA) expression, cDNA synthesis by the RT-Avd complex, and site-specific integration into the variable repeat (VR) of a target gene. A prototypical retron is shown with the initiation of cDNA synthesis at a branched guanosine in retron msr RNA. The resulting msr-msd molecule may interact with products of one or more effector genes to make up multipartite retron defense systems

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