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Fig. 4 | Mobile DNA

Fig. 4

From: KRAB zinc finger protein ZNF676 controls the transcriptional influence of LTR12-related endogenous retrovirus sequences

Fig. 4

KZFPs such as ZNF676 are candidates for protecting LTR12C elements against genome-wide demethylation in human PGC development. A ZNF676 expression across hPGC development. RNA-seq data from [77]. B Heatmap depicting average DNA methylation levels per TE subfamily across male and female hPGC development. RRBS data from Guo et al. [28]. Most methylated TE families represented. C Boxplots representing RRBS DNA methylation levels in female hPGC at week 10 of development across LTR12C loci known to belong to the maternal or ZGA clusters. Wilcoxon test for significance. D Boxplots representing RRBS DNA methylation levels in female hPGC at week 10 of development across LTR12C loci identified as ChIP-seq targets or non-targets of ZNF676 (consensus of 3 replicates in HEK293T cells). Wilcoxon test for significance

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ISSN: 1759-8753