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Fig. 4 | Mobile DNA

Fig. 4

From: Whole-genome analysis reveals the contribution of non-coding de novo transposon insertions to autism spectrum disorder

Fig. 4

Genomic distribution of polymorphic and de novo TEIs. A 10,000 random simulations were performed for both polymorphic and de novo TEIs based on the observed rates. Log2 fold change of observed compared to expected counts in different genomic regions are shown for coding and gene regulatory regions. 95% confidence intervals were estimated based on the empirical distribution of the random simulations. Polymorphic TEIs from parental individuals are depleted in exons and regulatory regions in the developing fetal brain. De novo Alu (A) and L1 insertions (B) do not show this depletion compared to 10,000 random simulations. Two-sided empirical p-values and Benjamini–Yekutieli q-values based on multiple correction of all enrichment and depletions performed are represented

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