Skip to main content
Fig. 5 | Mobile DNA

Fig. 5

From: Genomic approaches to trace the history of human brain evolution with an emerging opportunity for transposon profiling of ancient humans

Fig. 5

Leveraging ancient human genomes to understand the role of TEs in human brain evolution. First, profile polymorphic TE insertions in a large number of diverse ancient human genome sequencing data. Second, derive population genetic models to detect TEs under natural selection and/or perform functional annotation of TE insertions to create a refined list of polymorphic and reference TE insertion candidates. Third, conduct experimental validation of TE insertion candidates for their role in human brain evolution. Datasets and analytical outcomes are indicated with rounded rectangles; experimental procedures are indicated with rectangles; computational and statistical procedures are indicated with parallelograms. Dashed arrows indicate that after obtaining TE insertion profiles, researchers may use population genetic models and/or functional annotations to narrow down to a refined list of TE insertion candidates

Back to article page

Mobile DNA

ISSN: 1759-8753