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Fig. 1 | Mobile DNA

Fig. 1

From: The derepression of transposable elements in lung cells is associated with the inflammatory response and gene activation in idiopathic pulmonary fibrosis

Fig. 1

Changes in the expression of TE families in individual cell types and whole-lung tissue. a Bulk RNA-seq of whole-lung tissue (WL). b Bulk RNA-seq of flow cytometry-sorted alveolar type II cells (AT2). c Bulk RNA-seq of flow cytometry-sorted alveolar macrophages (AM). The TE expression was determined by read counts using the SQuIRE suite of tools, while the differential expression analysis was performed using the DESeq2 package in R. The x-axis represents the log2 ratio of the TE subfamily expression between the IPF patients and the donors. The y-axis represents the adjusted p-value based on -log10. The red color represents the TE subfamilies with a fold expression change (FC) > 1 and p.adjust < 0.05 (as represented by two vertical dotted lines, and the horizontal dotted line). The blue color represents the TEs with an adjusted p-value (p.adjust < 0.05, BH adjusted), while the green dots represent the TEs with an FC > 1. The black color represents changes that do not have a significant p.adjust value or an FC higher than 1. Different shapes represent different TE families

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ISSN: 1759-8753