Fig. 2

LINE-1 loci present in ORF1p IPs. a Total enrichment over input for loci with LINE-1 fully intact (green), with ORF2 truncated, but ORF1 intact (blue) and with ORF1 truncated (pink). Loci with intact ORF1 are more enriched than those with truncated ORF1. b Heatmap of the 10 most prevalent intact specific loci immunoprecipitated in each cell line. Fifteen additional loci in are shown in S2. 3′ transduction from the highlighted loci have been identified in prostate cancer [31, 45]. It is unclear whether the other expressed loci do not retrotranspose in prostate cancer, have not yet been identified due to limited analyses, or jump without forming 3′ transductions