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Fig. 4 | Mobile DNA

Fig. 4

From: Characterising a human endogenous retrovirus(HERV)-derived tumour-associated antigen: enriched RNA-Seq analysis of HERV-K(HML-2) in mantle cell lymphoma cell lines

Fig. 4

Relative expression of HML-2 proviruses in our and other studies. Relative expression of proviruses is shown as thickness of the pie slice. Env-encoding proviruses are indicated with an asterisk. Our three Mantle Cell Lymphoma cell lines – JVM2(Ion Torrent1–3 and minION), G519 and REC1 – are compared to published data from healthy donor lymphocytes, and other cancer cell lines and tissues (see text and Additional file 6 for details). The sequencing method is shown in parenthesis after the name. Results for Sanger and SMRT (Single Molecule Real Time) sequencing of three prostate biopsies are shown (one above the other) but note that the absence of provirus 22q11.23 from the Sanger sequencing is an artifact of the RT-PCR primers used (which incidentally were the same as those used in the melanoma and other cancers analysed by Sanger sequencing; note, PN233 is benign, the other two are cancerous). Results from two other lymphocyte donors not shown are very similar to the three shown here. The tandem duplication 7p22.1a + b (which have identical env sequences) are treated as one provirus in most studies so their expression values are combined here. Raw data available in Additional file 11

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