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Fig. 8 | Mobile DNA

Fig. 8

From: Identification of RAG-like transposons in protostomes suggests their ancient bilaterian origin

Fig. 8

Sequence variability mapped onto BbeRAG1L/2 L cryo-EM structure (PDB: 6B40). a, b, c, d Surface representation of sequence variability of the protein-DNA and protein-protein contact interfaces of RAG1L (a, b) or RAG2L (c, d) in a lateral view of a RAG1L-RAG2L heterodimer (a, c) or a top view of the RAG1L-RAG2L tetramer (b, d). Jensen-Shannon divergence (JSD) conservation score is displayed using a rainbow color code as indicated with the scale bar, with blue and red indicating highly conserved and highly variable positions, respectively. RAG2L and RAG1L are shown in gray in (a, b) and (c, d), respectively, while TIR DNA and TIR flanking DNA are shown in black and white, respectively. e, f Alternative models for the evolutionary relationship between Transib and the RAGL transposon. In the current model [16] (e), Transib was the ancestral element and the RAGL transposon was derived from Transib through acquisition of a RAG2L gene. In the alternative model (f), the RAGL transposon was ancestral and the first Transib transposon arose from a RAGL transposon by loss of RAG2L

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