Fig. 4
From: Identification of RAG-like transposons in protostomes suggests their ancient bilaterian origin
Protein domains found in protostome RAGL proteins. a Predicted domains present in the best preserved RAG1L and RAG2L proteins identified in this study (blue font) compared with RAG and RAGL protein sequences from deuterostomes (black font) and representative Transib transposase proteins (red font). All RAG1L and RAG2L proteins shown exist in tandem pairs with the exception of M. philippinarum RAG1L and RAG2L. Black lines, RAG1(L) and RAG2(L) core regions. Domains are not depicted to scale. RAG1L from S. glomerata is intact except for a premature stop codon in the ZnH2 domain. b, c Cartoon representations of the apo mouse RAG (i.e. in the absence of DNA) and B. belcheri RAGL (with DNA removed) tetramer structures, with domains colored as indicated and darker and lighter tones used to discriminate between subunits. Boundaries between domains are indicated with residue numbers. RAG1(L) domain abbreviations used: N-terminal zinc finger motifs, C1(*), C2(*), C3(*); ring zinc finger dimerization domain, ZDD(*); nonamer binding domain, NBD(*); dimerization and DNA binding domain, DDBD(*); pre-RNase H domain, PreR (*); catalytic RNase H domain, RNH(*); zinc finger ZnC2(*), zinc finger ZnH2(*),C-terminal domain, CTD(*); and C-terminal tail, CTT(*), that contains either the CCGHC motif of invertebrate RAG1L or acidic amino acids of vertebrate RAG1. RAG2(L) domain abbreviations used: 6-bladed kelch-type beta propeller domain, 6-Kelch(*); and plant homeodomain, PHD(*)