Fig. 4
From: A human endogenous retrovirus encoded protease potentially cleaves numerous cellular proteins
Gene Ontology term-based characteristics of human proteins identified as substrates of HERV-K(HML-2) Protease by TAILS. Selected cellular components (a) and biological processes (b) are depicted. Numbers were compiled using PANTHER (Protein ANalysis THrough Evolutionary Relationships) GO-Slim as provided at http://geneontology.org [51, 52]. Numbers of proteins per category expected by chance are also given. Graph (b) also depicts in the bottom-most bar the overlap of proteins identified by TAILS with cancer-relevant genes as compiled by COSMIC (Catalogue Of Somatic Mutations In Cancer; https://cancer.sanger.ac.uk/cosmic) [53]. See Additional file 1: Table S3 for COSMIC cancer genes