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Fig. 1 | Mobile DNA

Fig. 1

From: Human transposons are an abundant supply of transcription factor binding sites and promoter activities in breast cancer cell lines

Fig. 1

Enriched TE subfamilies in breast cancer-associated TFBSs. a 268 out of 1156 TE subfamilies, with representatives from all major classes, were found to be significantly enriched in breast cancer-associated TFBSs, as identified by a binomial test, where p < 4.3E-5 indicated statistical significance. The abundance of TE subfamilies in the human genome, categorised into classes, are shown for reference. b Heatmap demonstrates the level of enrichment of the most highly enriched TE subfamilies (> 7.5 enrichment ratio in all TF datasets) (ER = Enrichment Ratio). c Subfamilies enriched in the binding sites of C/EBPβ, E2F1 and MYC were investigated for their association with histone marks (H3K27ac, H3K4me1, H3K4me3, H3K36me3, H3K9me3 and H3K27me3) in MCF7 cells using published ChIP-seq datasets. The left panels display the histone modification profile of TE elements containing TFBSs, while the right panels display the profile of TE elements lacking TFBSs. The average RPKM values at 50 bp resolution over a 10 kb region centred on the TEs (filled ractangles) are plotted for i) MIRb and ii) L2a

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