Skip to main content

Table 3 MLV Insertions

From: Mouse germ line mutations due to retrotransposon insertions

Mutation

MGI IDa

Strain of origin

ERV location, orientationb

Mutational mechanisms or effects

References

Abcb1a mds

3044239

CF-1

Solitary MLV LTR, Intron 22, −

Transcripts contain viral sequence, Exon skipping, Disruption of gene function.

[258, 259]

Aifm1 Hq

1861097

CF-1

Intron 1, +

80% decrease in transcript and protein levels, Aberrant splicing

[260]

Hr hr

1856057

HRS/J

Intron 6, +

Transcripts contain viral sequence, Probable termination within LTR

[24, 137]

Lamc2 jeb

3609880

129X1/SvJ

Solitary MLV LTR, intron 18, +

Aberrant splicing and premature termination, low level of normal transcripts

[261]

Lmf1 cld

1856820

M. m. musculus

Intron 7,?

Transcripts contain ERV sequence, Termination within ERV

[262]

Myo5a d

1856004

Fancy mice

Intron, +

Shortened and abnormally spliced transcripts that vary among tissues

[135]

Pde6b rd1

1856373

unknown

Intron 1, −

Associated with nonsense mutation in gene but effect of ERV is unclear

[263]

  1. aID number in Mouse Genome Informatics (MGI) database
  2. b- = antisense, + = sense,? = orientation unknown