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Fig. 7 | Mobile DNA

Fig. 7

From: Phylogenomic analysis reveals splicing as a mechanism of parallel evolution of non-canonical SVAs in hominine primates

Fig. 7

Parallel evolution of SVA structural variants in humans and chimpanzees. a Schematic representation of SVA_F1 (human) and pt_SVA_D6 (chimpanzee) elements. In both cases the 5’ Alu-like region is replaced by the GC-rich first exon of a gene encoding a serine-threonine kinase: MAST2 in SVA_F1 and STK40 in pt_SVA_D6. b Length distribution of the acquired exon sequences for SVA_F1 and pt_SVA_D6. Identical lengths of MAST2/STK40 acquired sequences in multiple elements are represented only once. The data for SVA_F1 were taken from Damert et al. [6]. c Multiple alignments of canonical SVA (Alu-like) sequences (SVA_D and SVA_F), the first exons of MAST2 and STK40, and the resulting SVA_F1 and pt_SVA_D6 elements. The splice acceptor “AG” is highlighted in yellow. H10_1: SVA_F1 source element [6]

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