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Fig. 4 | Mobile DNA

Fig. 4

From: Detection of the LINE-1 retrotransposon RNA-binding protein ORF1p in different anatomical regions of the human brain

Fig. 4

Nuclear-cytoplasmic localization of endogenous ORF1p in frontal cortex and hippocampal sections obtained from 55 year- and 80 year-old brain. a Differences in the abundance of nuclear-localized ORF1p between frontal cortex relative to hippocampal section from 80 year-old. Immunohistochemistry analysis was carried as described in methods using α-L1 ORF1p (RRM). b Detection of L1 ORF1p in total lysate from 80 year old frontal cortex by Western blotting. α-human L1 ORF1p (RRM) detects ORF1p (~40 kDa) in total lysate from 80 year old frontal cortex (lane 2). Total lysate from MCF-7 cells was used as control (lane 1)

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