From: Endogenous retroviral promoter exaptation in human cancer
Genea | Gene function | Primary result of TE-driven expression | TE type | TE promoter coordinates (hg38) | Cancer type | references |
---|---|---|---|---|---|---|
CSF1R | Tyrosine kinase receptor | Ectopic expression of normal protein | (ERVL-MaLR) THE1B LTR | chr5:150092453–150092809 | HL | [113] |
IRF5 | Transcription factor | Ectopic expression of normal protein | (ERV1) LOR1a LTR | chr7:128936859–128937097 | HL | |
MET | Tyrosine kinase receptor | Protein truncation | (L1) L1PA2 | chr7:116718498–116724489 | CML, others? | |
ALK | Tyrosine kinase receptor | Protein truncation | (ERVL) LTR16B2 | chr2:29223783–29224196 | melanoma | [38] |
ERRB4 | Tyrosine kinase receptor | Protein truncation | (ERVL-MaLR) MLT1C LTR (ERVL-MaLR) MLT1H2 LTR | chr2:211693702–211694209 chr2:211465146–211465419 | ALCL | [129] |
SLCO1B3 | Anion transporter | Chimeric protein | (ERV1) LTR7b | chr12:20822187–20822617 | colon, others | |
FABP7 | Fatty acid binding | Chimeric protein | (ERV1) LTR2 | chr6:122748805–122749262 | DLBCL | [138] |