Fig. 2

a UCSC Genome Browser view (hg19) of a portion of the human ALK gene. ALK exon 20 (large blue box) and a part of the upstream intron are shown, with direction of transcription from right to left. The LTR16B2 alternative promoter shown in the Repeatmasker track as an orange box and the 25 bp region of clustered TSSs in melanoma cells, identified using 5’ RACE by Weiser et al. [38], is shown as a green box The CAGE track above is from the Fantom5 project [128], with transcriptional direction indicated with a blue arrow. Most CAGE tags are from monocyte-derived macrophages and endothelial progenitor cells. b UCSC Genome Browser view (hg19) of the region encompassing the SAMMSON lncRNA, which plays an oncogenic role in melanoma [161]. The LTR1A2 promoter is indicated in the Repeatmasker track as an orange box. The ChIP-Seq track for SOX10 was created from a dataset (NCBI Gene Expression Omnibus: GSE61967) generated by Laurette et al. [225] in the 501Mel melanoma cell line