Table 1 Published analyses of L1-associated mutations in brain tumours
Study | Brain tumour types (sample count) | Sequencing method | L1 coverage (tumour) | Potential somatic L1-associated mutations (PCR validated) | Ref. |
|---|---|---|---|---|---|
Iskow et al. | GBM (5), medulloblastoma (5) | L1-seq | 3.6× - 6.4× | 74 (0) | [30] |
Lee et al. | GBM (16) | WGS | 39.2× | 16 (0) | [32] |
Brennan et al. | GBM (42) | WGS | 35.3× | 0 (0) | [6] |
Helman et al. | GBM (20) | WGS | 40.8× | 0 (0) | [35] |
Tubio et al. | Glioma cell line (1) | WGS | 42.6× | 1 (0) | [31] |
Carreira et al. | GBM (9), glioma (5) | RC-seq | 43.2×–231.0× | 4 (2) | – |