Spotting the enemy within: Targeted silencing of foreign DNA in mammalian genomes by the Krüppel-associated box zinc finger protein family

Table 1 KRAB-ZFPs reported to bind to exogenous/endogenous retroviruses and other EREs

KRAB-ZFP	Organism	Target	Motif	Supporting evidence	Reference
ZFP809	Mouse	MuLV, VL30	18 bp	ChIP-seq, KO, Rep, EMSA	[7], [112]
ZFP819	Mouse	IAP, LINE	n.d.	ChIP, KD, Rep	[116]
Gm6871	Mouse	LINE	18 bp	ChIP-seq, KD, Rep	[10]
ZNF350	Human	HIV	21 bp	ChIP, Rep	[122]
ZNF175	Human	HIV	11/17 bp	Rep	[121]
ZNF10	Human	HIV	n.d.	Rep, KD, EMSA	[123]
ZNF282	Human	HTLV	8 bp	Rep, EMSA	[53]
ZNF91	Human	SVA	>60 bp	Rep	[8]
ZNF93	Human	L1	51 bp	ChIP-seq, Rep	[8]
Various ZNFs	Human	Various EREs	9-18 bp	ChIP-seq	[9]

KO genetic knockout studies, Rep reporter assays, KD knockdown by siRNA, EMSA electrophoretic mobility shift assays, n.d. not determined

ISSN: 1759-8753