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Fig. 3 | Mobile DNA

Fig. 3

From: Spotting the enemy within: Targeted silencing of foreign DNA in mammalian genomes by the Krüppel-associated box zinc finger protein family

Fig. 3

Phylogenetic tree of mouse and human KRAB-ZFPs. 277 mouse (green circles) and 339 human (red circles) KRAB-ZFP sequences (all proteins with both KRAB and C2H2 zinc finger domains) were retrieved from the UCSC Gene Sorter tool (https://genome.ucsc.edu/). KRAB domains were annotated through a Pfam domain (PF01352) screen (http://pfam.xfam.org/), extracted, and aligned with MUSCLE [197] to infer a Maximum-likelihood phylogenetic tree using MEGA version 6 with default parameters [198]. All KRAB sequences are provided as Additional file 1. Exemplary proportions of the tree that contain ERE-silencing KRAB-ZFPs or KRAB-ZFPs conserved between mouse and human (e.g., PRDM9, ZNF282, and ZNF777) are shown in more detail

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