Distinct features of the piRNA pathway in somatic and germ cells: from piRNA cluster transcription to piRNA processing and amplification

Théron, Emmanuelle; Dennis, Cynthia; Brasset, Emilie; Vaury, Chantal

doi:10.1186/s13100-014-0028-y

Mobile DNA

Table 1 Factors required for the piRNA pathway

From: Distinct features of the piRNA pathway in somatic and germ cells: from piRNA cluster transcription to piRNA processing and amplification

Protein	Physical interactions	Fertility of mutants	Homologs in other species	References
Primary piRNA pathway
Yb	Vret, Armi	Female sterile	ND	[28]
Yb	Vret, Armi	Male sterile	ND	[28]
Zucchini (Zuc)	Aub	Female sterile	Mouse: MitoPLD	[38]
Zucchini (Zuc)	Aub	Female sterile	MMZuc or Pld6	[38]
Armitage (Armi)	Yb, Piwi, Vret	Female sterile	Mouse: Mov10L1	[28],[32]
Armitage (Armi)	Yb, Piwi, Vret	Partial male sterile	Mouse: Mov10L1	[28],[32]
Sister of Yb (SoYb)	Vret^a	ND	ND	[28]
Vreteno (Vret)	SoYB^a, BoYB^a, YB, Aub, Armi, AGO3, Piwi	Female sterile	Mouse: Tdrd1	[28],[32]
Vreteno (Vret)	SoYB^a, BoYB^a, YB, Aub, Armi, AGO3, Piwi	Male sterile	Mouse: Tdrd1	[28],[32]
Gasz	Karyβ3^a	Female sterile	Mouse: Gasz	[34]
Shutdown (Shu)	ND	ND	Mouse: Fkbp6	[29]
Hen1	Piwi	Fertile	Mouse: Hen1	[39]
Brother of Yb (BoYb)	Vret^a	Partial female sterile	Mouse: Tdrd12	[28]
Secondary piRNA pathway
Krimper (Krimp)	ND	Female sterile	ND	[40]
Aubergine (Aub)	AGO3, Qin/Kumo, Squ, Tej, Vret, Zuc, Tap	Female sterile	Mouse: Mili	[41],[42]
Aubergine (Aub)	AGO3, Qin/Kumo, Squ, Tej, Vret, Zuc, Tap	Male sterile	Mouse: Mili	[41],[42]
AGO3	Aub,Vret	Female sterile		[32],[42]
AGO3	Aub,Vret	Partial male sterile		[32],[42]
Vasa	Qin/Kumo, Tej, Tap	Female sterile	Mouse: Mvh, B. mori: Vasa	[41],[43]
Vasa	Qin/Kumo, Tej, Tap	Male sterile	Mouse: Mvh, B. mori: Vasa	[41],[43]
Spindle-E (Spn-E)	Qin/Kumo, Tej, Tap	Female sterile	Mouse: Tdrd9	[41],[43]
Spindle-E (Spn-E)	Qin/Kumo, Tej, Tap	Male sterile	Mouse: Tdrd9	[41],[43]
Papi	ND	ND	Mouse: Tdrd2	[44]
Tejas (Tej)	Aub, Spn-E, Vasa, Tap	Female sterile,	Mouse: Tdrd5	[43]
Tejas (Tej)	Aub, Spn-E, Vasa, Tap	Male fertile	Mouse: Tdrd5	[43]
Tapas, (Tap)	SpnE, Aub, Tej, Vasa	Fertile	Mouse: Tdrd7	[45]
Qin/Kumo	HP1, Aub, Piwi, Spn-E, Vasa	Female sterile	Mouse: Rnf17	[41],[42]
TE Transcriptional silencing
Piwi	Hen1, Armi, Arx, HP1, Qin/Kumo,Vret	Female sterile		[39],[46]
Piwi	Hen1, Armi, Arx, HP1, Qin/Kumo,Vret	Male sterile		[39],[46]
Mael		Female sterile	Mouse: Maelstrom	[31],[40]
Mael		Male sterile	Mouse: Maelstrom	[31],[40]
Asterix (Arx)	Piwi	Female sterile	Mouse: Gtsf1	[47]
Asterix (Arx)	Piwi	Male sterile	Mouse: Gtsf1	[39]

^aFlybase information.

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ISSN: 1759-8753

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